Korean J Hepatol.  2007 Sep;13(3):414-418. 10.3350/kjhep.2007.13.3.414.

Alfuzosin-induced Acute Liver Injury

• Kim SY
• Kim BH
• Dong SH
• Kim HJ
• Chang YW
• Chang R
• Kim YW

• KMID: 760743
• DOI: http://doi.org/10.3350/kjhep.2007.13.3.414

Abstract

We describe a 56-year-old man who developed an acute liver injury after taking alfuzosin for 1 month to control his newly diagnosed benign prostatic hypertrophy (BPH). There was no history of alcohol consumption or the taking herbal or traditional remedies. Viral causes, autoimmune hepatitis, and biliary tree obstruction were excluded. Other rare causes of hepatitis such as hemochromatosis, primary biliary cirrhosis and Wilson's disease were also absent in this patient. His liver test results began to improve after discontinuing the alfuzosin. Two weeks later, alfuzosin was administered again because the patient complained of dysuria. After 10 days of alfuzosin reuse, his liver test results worsened. Five months later after the complete discontinuation of the drug, his liver test results had returned to normal. This clinical sequence suggests that alfuzosin caused his acute liver injury.

Keyword

Alfuzosin; Hepatitis, toxic; Benign prostatic hyperplasia

MeSH Terms

Acute Disease
Adrenergic alpha-Antagonists/*adverse effects
Dysuria/pathology
Humans
Liver Diseases/*chemically induced/pathology
Liver Function Tests
Male
Middle Aged
Prostatic Hyperplasia/drug therapy
Quinazolines/*adverse effects