Korean J Hepatol.  2007 Mar;13(1):96-102.

A Case of the Treatment in an Adult with Hepatic Undifferentiated (Embryonal) Sarcoma

• Kim KT
• Han SY
• Park EH
• Jang JS
• Roh MH
• Lee SW
• Jeong JS

Abstract

Undifferentiated embryonal sarcoma is a rare primary malignant neoplasm of the liver. Undifferentiated sarcoma of the liver in adult is an uncommon hepatic tumor of mesenchymal origin, generally considered an aggressive neoplasm with an unfavorable prognosis. We present a case of undifferentiated sarcoma in a 61-year-old woman. CT scan demonstrated a large heterogenous, exophytic growing hepatic mass in the right lobe with pulmonary metastatic nodules. US guided liver biopsy was done and pathological findings of the liver specimen revealed that isolated or grouped round pleomorphic cells and spindle to stellate cells were present. Immunohistochemical stain showed that tumor cells expressed positivity for vimentin and partially positivity or negativity for cytokeratin. She was diagnosed as having undifferentiated sarcoma of the liver. She received seven courses of VAIA chemotherapy by CWS protocols. Chemotherapy was efficacious and the size of the tumor decreased considerably after the treatment. No tumor recurrence for 12 months is noted.

Keyword

Sarcoma; Liver; Chemotherapy

MeSH Terms

Antineoplastic Combined Chemotherapy Protocols/therapeutic use
Dactinomycin/therapeutic use
Doxorubicin/therapeutic use
Female
Humans
Ifosfamide/therapeutic use
Liver Neoplasms/*diagnosis/*drug therapy/pathology
Middle Aged
Sarcoma/*diagnosis/*drug therapy/pathology
Tomography, X-Ray Computed
Vincristine/therapeutic use