Korean J Intern Med.  2002 Sep;17(3):198-203.

Lymphocytic Interstitial Pneumonitis Associated with Epstein-Barr virus in Systemic Lupus Erythematosus and Sjgren's Syndrome: Complete remission with corticosteroid and cyclophosphamide

• Yum HK
• Kim ES
• Ok KS
• Lee HK
• Choi SJ

Abstract

Lymphocytic interstitial pneumonitis (LIP) is characterized by diffuse bilateral pulmonary infiltrations in both lower lobes. Pleomorphic lymphohistiocytes including mature lymphocytes, variable admixture of plasma cells and other mononuclear cells infiltrate within the pulmonary interstitium, ranging from widened septa to confluent masses. We report a case of LIP associated with Epstein-Barr virus in a patient with SLE and Sj gren's syndrome. A 50-year-old woman was admitted with insidious onset of progressive dyspnea for 20 days. She suffered from arthritis 10 years earlier without specific diagnosis. A radiography of chest has showed bilateral consolidative infiltrations with pleural effusion in both lower lung fields. Open lung biopsy documented lymphocytic interstitial pneumonitis which expressed Epstein-Barr virus genome in situ hybridization study. Following corticosteroid and cyclophosphamide therapy, clinical symptoms and radiologic infiltrations gradually remitted.

Keyword

Lymphocytic interstitial pneumonitis (LIP); Systemic Lupus Erythematosus (SLE); Sj gren's syndrome; Epstein-Barr virus

MeSH Terms

Case Report
Cyclophosphamide/therapeutic use
Female
Glucocorticoids, Synthetic/therapeutic use
Herpesviridae Infections/*complications
*Herpesvirus 4, Human
Human
Immunosuppressive Agents/therapeutic use
Lung Diseases, Interstitial/*complications/drug therapy
Lupus Erythematosus, Systemic/*complications
Middle Age
Prednisone/therapeutic use
Sjogren's Syndrome/*complications