Korean J Hematol.  2009 Dec;44(4):273-277. 10.5045/kjh.2009.44.4.273.

A Case of a Synchronous Peripheral T-cell Lymphoma in a Patient with Systemic Lupus Erythematosus

• Sung HJ
• Seo KI
• Hong JH
• Roh SY
• Hong YS
• Ko YH

• KMID: 2252109
• DOI: http://doi.org/10.5045/kjh.2009.44.4.273

Abstract

Systemic lupus erythematosus (SLE) patients tends to have a higher risk of developing lymphoid malignancies. The majority of such tumors are of a B cell origin. However, it is known that the T cell lymphoma subtypes in SLE patients are quite rare. Here, we describe a case of peripheral T cell lymphoma, unspecified (PTCL-U) that occurred in a 50-year-old female SLE patient. The lymphoma was located at the bilateral cervical and mediastinal lymph nodes. The staging workup revealed no evidence of any other organ involvement. Epstein-Barr virus messenger RNA was detected in the serum, but not in the lymph nodes. She received front-line chemotherapy with the CHOP regimen and she achieved complete remission. She then subsequently received high-dose chemotherapy with autologous peripheral stem cell transplantation. The patient currently remains in a clinical and serological state of remission for the SLE and PTCL until the time of this report 18 months after chemotherapy, and this was followed by autologous peripheral blood stem cell transplantation.

Keyword

Lymphoma; T cell; Peripheral; Lupus erythematosus; Systemic; Peripheral blood stem cell transplantation

MeSH Terms

Antineoplastic Combined Chemotherapy Protocols
Cyclophosphamide
Doxorubicin
Female
Herpesvirus 4, Human
Humans
Lupus Erythematosus, Systemic
Lymph Nodes
Lymphoma
Lymphoma, T-Cell
Lymphoma, T-Cell, Peripheral
Middle Aged
Peripheral Blood Stem Cell Transplantation
Prednisolone
RNA, Messenger
Vincristine
Antineoplastic Combined Chemotherapy Protocols
Cyclophosphamide
Doxorubicin
Prednisolone
RNA, Messenger
Vincristine

Figure

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  Fig. 1. Lymphoma cells are small-to-medium in size and have oval-shaped nuclei with irregular contours, coarse chromatin, and moderate amounts of pale cytoplasm (H&E, ×400).

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  Fig. 2. Immunohistochemistry, showing the cells to be strongly positive for the T-cell marker CD3 (×400).

Reference

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