Korean J Intern Med.  1998 Jul;13(2):83-87.

IgE production from the nasal polyp tissue: comparison between atopic and non-atopic subjects

• Kim HY
• Nahm DH
• Suh KS
• Park HS

Abstract

OBJECTIVES
AND METHODS: To confirm the local production of IgE antibody from the nasal polyp tissue, and to evaluate the difference between atopics and non-atopics, nasal polyp tissues were taken from both 10 atopic and 10 non-atopic subjects. The tissue total IgE (tlgE) level was measured by enzyme-linked immunosorbent assay (ELISA) and serum tlgE level by radio-immunoassay. The tissue albumin level was measured by nephelometry, and serum albumin level by Bromocresol green method. RESULTS: The polyp tissue tlgE/albumin as well as serum tlgE/albumin ratio were significantly higher in atopics than in non-atopics (p < 0.05), with no difference in the albumin level between the two groups (p > 0.05). Three non-atopic subjects had high polyp tissue tlgE/albumin (> 10). A significant correlation was noted between serum tlgE/albumin and polyp tlgE/albumin (r = 0.46, p = 0.04). The ratio of polyp tlgE/albumin to serum tlgE/albumin was greater than 1 in all of the non-atopic subjects and 7 of 10 atopic subjects. CONCLUSION: These findings support the hypothesis that IgE antibody could be locally produced from the nasal polyp tissue of non-atopic subjects as well as atopic subjects. The possibility of an isolated local production of IgE antibody was suggested.

MeSH Terms

Albumins/analysis
Antibodies, Anti-Idiotypic/analysis*
Biopsy, Needle
Comparative Study
Enzyme-Linked Immunosorbent Assay
Female
Human
Hypersensitivity, Immediate/immunology*
IgE/biosynthesis*
IgE/analysis
Male
Nasal Polyps/pathology
Nasal Polyps/immunology*
Radioimmunoassay
Reference Values
Tissue Culture
Substances: IgE
Substances: Antibodies, Anti-Idiotypic
Substances: Albumins