Yonsei Med J.  1998 Dec;39(6):595-603. 10.3349/ymj.1998.39.6.595.

Antibiotic use at a pediatric age

• Kim DS
• Park MS

• KMID: 711603
• DOI: http://doi.org/10.3349/ymj.1998.39.6.595

Abstract

For infections in infants and children, the successful antibiotic treatment depends primarily on rapid diagnosis of the disease, identification of pathogenic microorganisms, and appropriate application of specialized pharmacokinetic and pharmacodynamic knowledge of antibiotics in children. In infants and children, the absorption, distribution, metabolism, and excretion of drugs may differ considerably in comparison with adults. Because of known toxicity, certain drugs such as chloramphenicol in high doses, the sulfonamides, and tetracycline should not be used in neonates. In this article, we describe these peculiarities of children and discuss the proper use of antibiotics in children.

Keyword

Antibiotics; pediatrics

MeSH Terms

Antibiotics/therapeutic use*
Antibiotics/pharmacokinetics
Antibiotics/metabolism
Antibiotics/administration & dosage
Child, Preschool
Dose-Response Relationship, Drug
Human
Infant
Pediatrics/methods*
Time Factors