Yonsei Med J.  1989 Jun;30(2):186-192. 10.3349/ymj.1989.30.2.186.

The significance of specific IgE and IgG to dermatophagoides farinae according to the types of asthmatic reaction in house dust asthmatics

Affiliations
  • 1Department of Internal Meidcine, Yosnei University College of Medicine, Korea.

Abstract

To investigate the role of specific IgE and IgG in the various types of asthmatic reaction, we measured specific IgE and IgG levels to Dermatophagoides farinae (D.farinae) using the D. farinae-radioallergosorbent test (RAST) and Phadebas IgG-RAST in 39 house dust asthmatics (11 early responders, 21 dual responders and 7 isolated late responders) and 12 negative responders on house dust bronchoprovocation. There were significant differences in the D. farinae-specific IgE level and skin reactivity to D. farinae and house dust among the 4 groups (p less than 0.05) and the specific IgE level of dual asthmatic responders was the highest and was significantly higher than that of early responders (p less than 0.05). The specific IgG level showed no differences among the 4 groups. These results suggested that the types of asthmatic reaction in house dust asthmatics were closely related to specific IgE level to D. farinae and the specific IgG level seemed not to be related to an isolated late response.

Keyword

D. farinae specific IgE and IgG level; bronchoprovocation test

MeSH Terms

Adolescent
Adult
Animal
Antibody Specificity
Asthma/etiology/*immunology
Bronchial Provocation Tests
Dust/adverse effects
Female
Human
Immunoglobulin E/metabolism
Immunoglobulin G/metabolism
Male
Middle Age
Mites/*immunology
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