Yonsei Med J.  1985 Jun;26(1):1-7. 10.3349/ymj.1985.26.1.1.

Adjuvant Treatment with Chemotherapeutic Agents and Polyadenylic-Polyuridylic Acid in Operable Stomach Cancers: I. Enhancement of Natural Killer Cell Activity

• Youn JK
• Kim BS
• Min JS
• Choi HJ
• Lee YB
• Lee DW
• Koh EH
• Kim KW
• Lee KB
• Michelson

• KMID: 692984
• DOI: http://doi.org/10.3349/ymj.1985.26.1.1

Abstract

Natural Killer (NK) cell activity of 47 operable stomach cancer patients was sequentially studied before and after chemotherapy in association with polyadenylic. polyuridylic acid [poly(A).poly(U)]. NK activity was determined by an in vitro 4 h chromium release assay using nonadherent mononuclear cells isolated from peripheral bloods as effectors and human myeloblastic cells (K562) as targets. The following results were obtained: 1) The mean NK activity of the 47 patients tested before chemotherapy was significantly lower than that of 14 healthy controls. 2) The patents who received chemotherapy consisting of 5 FU (12 mg/kg) and adriamycin (40 mg/M2) showed an increase in NK activity 5 days after injection as compared to that of the same patients tested before chemotherapy. 3) In these patients, an additional administration of poly(A) poly(U) (100mg) resulted in a further significant increase of NK activity 2 days later, whereas the control patients who received placebo showed no change of NK activity.

Keyword

Stomach cancer; NK activity; chemotherapy; poly(A).poly(U)

MeSH Terms

Adult
Aged
Combined Modality Therapy
Doxorubicin/therapeutic use
Female
Fluorouracil/therapeutic use
Human
Killer Cells, Natural/drug effects*
Male
Middle Age
Poly A-U/pharmacology
Poly A-U/therapeutic use*
Stimulation, Chemical
Stomach Neoplasms/drug therapy*
Stomach Neoplasms/surgery