Yonsei Med J.  1970 Dec;11(2):173-181. 10.3349/ymj.1970.11.2.173.

Hodgkin's Disease Complicated by Cryptococcemia: One Case Report

• Choi HY
• Choe JK
• Lee YB

• KMID: 687647
• DOI: http://doi.org/10.3349/ymj.1970.11.2.173

Abstract

A case of Hodgkin's disease which was complicated by disseminated cryptococcemia terminally is reported. The patient was a 19 year old girl and complained of high fever with shaking chins and dyspnea. In the past history, antituberculous treatment was given using PAS, INH and streptomycin for 2 months under the diagnosis of tuberculous pleurisy and several antibiotics and steroids were also given. On admission, antituberculous treatment was continued and prednisolone was also prescribed. She was discharged 15 days later but was readmitted because of abdominal pain and uncontrolable fever. On the third hospital day, a leftcervical lymphnode biopsy revealed. Hodgkin's disease, paragranuloma type. Endoxan and cobalt 60 irradiation were given to the abdomen. On the sixtieth hospital day, she became irritable and comatose and expired. At autopsy, disseminated Hodgkin's sarcoma was noted involving multiple lymphnodes, esophagus, small and large intestines, pancreas, liver, spleen, diaphragm, lungs, peritoneum, uterus, left ovary and bone marrow. In addition, evidence of cryptococcemia involving kidneys, lungs, heart, brain, pituitary gland and lymphnodes, was noted. A brief review of the literature was also made.

MeSH Terms

Adult
Autopsy
Cryptococcosis/complications*
Cryptococcosis/pathology
Female
Hodgkin Disease/complications*
Hodgkin Disease/pathology
Human
Lymph Nodes/pathology
Septicemia/etiology*