Korean J Pathol.  1995 Dec;29(6):804-806.

Interfollicular Hodgkin's Lymphoma: A case report

• Maeng LS
• Kim KM
• Kang YM
• Kang CS
• Shim SI

Abstract

An unusual pattern of focal involvement of lymph nodes by Hodgkin's disease is described using the name Interfollicular Hodgkin's Disease. It is characterized by florid reactive follicular hyperplasia which overshadows involvement of the interfollicular zones by Hodgkin's desease. The importance of interfollicular Hodgkin's disease rests on its misdiagnosis as a benign lesion. We report a case of interfollicular Hodgkin's disease in a 34-year-old female patient in the inguinal area. The lymph nodes showed reactive follicular hyperplasia. The focal interfollicular spaces were invaded by Hodgkin's disease. The Reed-Stemberg cells stained positively with CD15 and CD30 antibody in the immunohistochemical stain. An in situ hybridization study looking for EBV was negative in these R-S cells.

Keyword

Hodgkin's disease; Interfollicular; Immunohistochemical; In situ hybridization

MeSH Terms

Adult
Diagnostic Errors
Female
Herpesvirus 4, Human
Hodgkin Disease*
Humans
Hyperplasia
In Situ Hybridization
Lymph Nodes