J Korean Med Sci.  2002 Dec;17(6):749-754. 10.3346/jkms.2002.17.6.749.

The Skeletal Site-Differential Changes in Bone Mineral Density Following Bone Marrow Transplantation: 3-Year Prospective Study

• Lee WY
• Kang MI
• Baek KH
• Oh ES
• Oh KW
• Lee KW
• Kim SW
• Kim CC

• KMID: 648782
• DOI: http://doi.org/10.3346/jkms.2002.17.6.749

Abstract

Loss of bone mass is usually detected after bone marrow transplantation (BMT) during the early post-transplant period. However, little is known about the long-term effects of BMT on bone metabolism. We have prospectively investigated 11 patients undergoing BMT. Bone mineral density (BMD) was measured before BMT, and 1, 2, and 3 yr after BMT. Serum markers of bone turnover were serially measured before BMT and 1, 2, 3, 4, and 12 weeks, 6 months, and 1 yr after BMT. The mean change in the lumbar spine (L2-4) BMD, calculated as the percent change from the baseline to the level at 1, 2, and 3 yr was -4.7% (NS), -1.1% (NS), and +6.4% (p<0.05), respectively. The mean change in the total proximal femur BMD from the baseline to the level at 1, 2, and 3 yr was -8.5% (p<0.01), -8.7% (p<0.05) and -5.6% (p<0.05), respectively. In summary, there was little decline in lumbar BMD at 1 yr following BMT and gradual recovery until 3 yr. In contrast, femoral BMD decreased much more than the lumbar area at 1 yr and did not recover until 3 yr. The mechanism of skeletal site-selective differences in the changes of BMD needs to be elucidated.

Keyword

Bone Marrow Transplantation; Bone Density

MeSH Terms

Adult
Age Factors
Anemia, Aplastic/therapy
*Bone Density
Bone Marrow Transplantation
Bone and Bones/drug effects/*metabolism/radiation effects
Collagen/blood
Collagen Type I
Cyclophosphamide/therapeutic use
Estradiol/blood
Follicle Stimulating Hormone/blood
Humans
Leukemia/therapy
Luteinizing Hormone/blood
Middle Aged
Myelodysplastic Syndromes/therapy
Peptides/blood
Prospective Studies
Time Factors