J Korean Med Sci.  1999 Dec;14(6):671-674. 10.3346/jkms.1999.14.6.671.

Hepatosplenic B-cell lymphoma associated with hemophagocytic syndrome: a case report

• Kwon SY
• Lee JJ
• Chung IJ
• Kim HJ
• Park MR
• Kim HS
• Park CS

• KMID: 646045
• DOI: http://doi.org/10.3346/jkms.1999.14.6.671

Abstract

While T-cell non-Hodgkin's lymphoma (NHL) associated with hemophagocytic syndrome (HPS) has been frequently observed, B-cell NHL associated with HPS has been rarely reported. We report a case of hepatosplenic B-cell lymphoma associated with HPS in a 41-year-old woman who presented with fever of unknown origin. An abdominal CT scan revealed splenomegaly with focal splenic infarction. Splenectomy and a liver wedge biopsy showed sinusoidal-pattern infiltration of medium to large tumor cells with positive reaction to a B-lymphocyte marker. Findings on bone marrow examination showed proliferation of histiocytes with avid hemophagocytosis.

Keyword

Lymphoma, B-cell; Histiocytosis, malignant; Liver neoplasms; Splenic neoplasms; Neoplasms, multiple primary

MeSH Terms

Adult
Antigens, CD/analysis
Antineoplastic Agents, Combined/therapeutic use
Bone Marrow Cells/pathology
Case Report
Female
Histiocytosis, Non-Langerhans-Cell/pathology
Histiocytosis, Non-Langerhans-Cell/complications*
Human
Liver Neoplasms/radiography
Liver Neoplasms/pathology
Liver Neoplasms/complications*
Lymphoma, B-Cell/radiography
Lymphoma, B-Cell/pathology
Lymphoma, B-Cell/complications*
Splenic Neoplasms/radiography
Splenic Neoplasms/pathology
Splenic Neoplasms/complications*
Splenomegaly/radiography
Tomography, X-Ray Computed
Tumor Markers, Biological/analysis