J Korean Med Sci.  1994 Aug;9(4):281-288. 10.3346/jkms.1994.9.4.281.

Prevalence of EBV RNA in sinonasal and Waldeyer's ring lymphomas

• Lee JH
• Lee SS
• Park JH
• Kim YW
• Yang MH

• KMID: 644810
• DOI: http://doi.org/10.3346/jkms.1994.9.4.281

Abstract

A high incidence of a T cell phenotype of sinonasal lymphomas in other Asian countries has been associated with a high incidence of Epstein Barr virus (EBV) infection. We analyzed 13 sinonasal and 18 Waldeyer's ring lymphomas for the prevalence of EBV encoded RNA (EBER) using a sensitive and specific in situ hybridization. In addition, we examined the relationship of histologic findings and immunophenotype as well as the location of the lymphomas to the presence of EBV. The EBER was detected in each of 12 sinonasal lymphomas with a T cell immunophenotype. One B cell sinonasal lymphoma was EBER negative. Four of 18 Waldeyer's ring lymphomas were positive for EBER, including two T cell lymphomas. Two of 16 B cell Waldeyer's ring lymphomas were EBER positive. Morphologically, 11 of 20 diffuse large cell lymphomas, 2 diffuse mixed small and large cell lymphomas, 2 of 4 immunoblastic lymphomas and 1 lymphoplasmacytic lymphoma were EBER positive. Four follicular large cell lymphomas were EBER negative. A characteristic angiocentric or angiodestructive pattern was found in most T cell lymphomas and EBER positive cases. These findings indicate that EBV infection is more strongly associated with the T cell immunophenotype, angiocentric pattern and sinonasal location of the lymphoma.

Keyword

EBV; sinonasal lymphomas; Waldeyer's ring lymphomas

MeSH Terms

Adult
Aged
B-Lymphocytes/immunology
Female
Herpesviridae Infections/*virology
Herpesvirus 4, Human/genetics/*isolation & purification
Human
Immunophenotyping
In Situ Hybridization
Incidence
Lymphoid Tissue/virology
Lymphoma, Non-Hodgkin/epidemiology/immunology/mortality/*virology
Male
Maxillary Neoplasms/epidemiology/immunology/mortality/*virology
Middle Age
Nasopharyngeal Neoplasms/epidemiology/immunology/mortality/*virology
Nose Neoplasms/epidemiology/immunology/mortality/*virology
Prevalence
RNA, Viral/*analysis
Support, Non-U.S. Gov't
Survival Rate
T-Lymphocytes/immunology
Tonsillar Neoplasms/epidemiology/immunology/mortality/*virology
Tumor Virus Infections/*virology