Korean J Otorhinolaryngol-Head Neck Surg.  2025 Apr;68(4):159-167. 10.3342/kjorl-hns.2024.00101.

Efficacy and Safety of Dupilumab for Chronic Rhinosinusitis With Nasal Polyps: A Retrospective Study of Every Month Injection

• Kang P
• Choi D
• Kwon J
• Kim J

• KMID: 2567114
• DOI: http://doi.org/10.3342/kjorl-hns.2024.00101

Abstract

Background and Objectives
Dupilumab is approved for the treatment of uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP) and has been shown to be relatively safe and effective in randomized controlled trials. As such, real-world effectiveness and safety data should be obtained.
Subjects and Method
We performed a retrospective review of patients with CRSwNP who received monthly treatment of dupilumab between January 2022 and June 2023. Reviewed for the study were the following: demographic data, comorbidities, the visual analogue scale (VAS) for nasal obstruction and sense of smell, identification scores of the Korean version Sniffin’ stikc II (KVSS II) test, nasal polyp score (NPS), and serum eosinophil count. Statistical analyses were performed for each clinical variable.
Results
A total of 76 patients (49 male, 27 female) were included in this study. The VAS scores decreased from 7.17 at the baseline to 4.51 at month 6; the KVSS II identification scores increased from 6.71 to 8.47, and the NPS decreased from 3.82 to 0.44. The sino-nasal outcome test-22 scores decreased from 36.29 at the baseline to 8.22 at month 6. The correlations between all clinical variables were statistically significant.
Conclusion
Monthly treatment of dupilumab is effective and safe for patients with CRSwNP. Further research is required to determine the predictive parameters for treatment responses and adverse events.

Keyword

Biologics; Nasal polyps; Sinusitis