J Rhinol.  2021 Nov;28(3):131-140. 10.18787/jr.2021.00382.

Practical Review of Biologics in Chronic Rhinosinusitis With Nasal Polyps

• Lee KI
• Ryu G
• Yoo SH
• Kim YM
• Mo JH
• Shin SH

• KMID: 2522781
• DOI: http://doi.org/10.18787/jr.2021.00382

Abstract

Well-characterized in chronic rhinosinusitis, type 2 inflammation is frequently associated with nasal polyps, comorbid asthma, and nonsteroidal anti-inflammatory drug hypersensitivity. Despite medical and surgical treatment, it recurs in a significant proportion of patients. Thus, severe uncontrolled type 2 chronic rhinosinusitis with nasal polyps is the most difficult-to-treat phenotype of chronic rhinosinusitis. Recently, dupilumab, a monoclonal antibody against IL-4 receptor α, and omalizumab, a monoclonal antibody against immunoglobulin E, were approved for patients with chronic rhinosinusitis with nasal polyps in the United States, Europe, and Korea. Therefore, rhinologists should understand novel biologics and their use. Here, we provide a literature review of several biologics with their indications, effectiveness, and safety.

Keyword

Biologics; Sinusitis; Immunology; Nasal polyps; Interleukin-4 receptors

Figure

• 

  Fig. 1. Immunological pathomechanism and biologics according to their targets in type 2 inflammation. Red starbursts focus the targets of novel biologics for chronic rhinosinusitis with nasal polyps (CRSwNP). Modified from Laidlaw et al. Ann Allergy Asthma Immunol 2020; 124(4): 326-32, with permission of Elsevier [55].

Reference

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