Infect Chemother.
2025 Mar;57(1):172-178. 10.3947/ic.2024.0130.
Poor Prognosis of Pneumococcal Co-Infection in Hospitalized Patients with COVID-19: A Propensity Score-Matched Analysis
- Hwang S
1,2 - Nam E1,2
- Kim SW1,3
- Chang HH1,3
- Kim Y1,3
- Bae S1,3
- Lee NY4
- Kim YK4
- Kim JS5
- Park HW1
- Bae JG1
- Jeong J2
- Kwon KT1,2
- Affiliations
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- 1Department of Medicine, School of Medicine, Kyungpook National University, Daegu, Korea
- 2Division of Infectious Diseases, Department of Internal Medicine, Kyungpook National University Chilgok Hospital, Daegu, Korea
- 3Division of Infectious Diseases, Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea
- 4Department of Clinical Pathology, School of Medicine, Kyungpook National University, Daegu, Korea
- 5Department of Medical Information, Kyungpook National University Hospital, Daegu, Korea
- KMID: 2566773
- DOI: http://doi.org/10.3947/ic.2024.0130
Abstract
- The impact of Streptococcus pneumoniae coinfection on coronavirus disease 2019 (COVID-19) prognosis remains uncertain. We conducted a retrospective analysis of patients hospitalized with COVID-19 who underwent a pneumococcal urinary antigen (PUA) test to assess its clinical utility. Results showed that PUA-positive patients required more oxygen support, high-flow nasal cannula, and dexamethasone compared to PUA-negative patients. Furthermore, the significantly higher incidence of a National Early Warning Score ≥5 in the PUA-positive group (P<0.001) suggests that a positive PUA test is associated with a severe disease course. However, no significant difference in mortality was observed between the two groups, and antibiotics were used in almost all patients (96.2%). While the PUA test may help guide antibiotic use in COVID-19 patients, its interpretation should be approached with caution.
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