J Korean Orthop Assoc.  2025 Mar;60(1):11-21. 10.4055/jkoa.2025.60.1.11 .

Regenerative Treatment of Cartilage in Early Osteoarthritis

Affiliations
  • 1Arthroscopy and Joint Research Institute, Yonsei University College of Medicine, Seoul, Korea
  • 2Department of Orthopedic Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
  • 3Department of Orthopaedic Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea

Abstract

Osteoarthritis is a disease that causes pain and decreased function due to the destruction of normal tissues of the joint with various causes. The knee is the most common joint affected by osteoarthritis, and numerous attempts have been made to treat early osteoarthritis. As treatments, various surgical techniques have been used to restore damaged cartilage. Each surgical procedure currently performed has its strengths and weaknesses. The criteria for selecting the surgical procedures have not been determined. This review article organizes the information and clinical results of cartilage restoration procedures, including marrow stimulation techniques and cell-based therapy.

Keyword

osteoarthritis; cartilage defect; marrow stimulation; autologous chondrocyte implantation; stem cell therapy
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