J Korean Soc Radiol.
2025 Jan;86(1):34-44. 10.3348/jksr.2024.0147.
Amyloid-Related Imaging Abnormalities in Anti-Amyloid Monoclonal Antibody Therapy for Alzheimer’s Disease: Expert Recommendation for Standard MRI Protocol
- Kim J
1 - Kim E2
- Park M3
- Bae YJ4
- Suh CH5
- You SH6
- Yim Y7
- Lee HJ8
- Choi JW9
- Oh SW1
- Moon WJ10
- for the KSNR Aging and NeuroDegeneration Imaging (ANDI) Study Group
- Affiliations
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- 1Department of Radiology, Eunpyeong St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
- 2Department of Radiology, Ewha Womans University Mokdong Hospital, Seoul, Korea
- 3Department of Radiology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
- 4Department of Radiology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea
- 5Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
- 6Department of Radiology, Anam Hospital, Korea University College of Medicine, Seoul, Korea
- 7Department of Radiology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea
- 8Department of Radiology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea
- 9Department of Radiology, Ajou University School of Medicine, Ajou University Medical Center, Suwon, Korea
- 10Department of Radiology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea
- KMID: 2564851
- DOI: http://doi.org/10.3348/jksr.2024.0147
Abstract
- The introduction of anti-amyloid therapies for Alzheimer’s disease (AD), such as lecanemab (Lequembi®), which was recently approved in Korea, necessitates careful monitoring for amyloid-related imaging abnormalities (ARIA) using brain MRI. To optimize ARIA monitoring in Korean clinical settings, the Korean Society of Neuroradiology (KSNR) and the Age and Neurodegeneration Imaging (ANDI) Study Group proposed MRI protocol recommendations on essential MR sequences, MRI acquisition parameters, timing and condition of MRI examinations, and essential details to provide a scientific basis for maximizing the safety and efficacy of AD treatment. A customized, standardized MRI protocol focusing on Korea’s healthcare environment can improve ARIA management and ensure patient safety through early detection of potential anti-amyloid therapy side effects, thereby enhancing treatment quality.
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