Korean J Pain.  2025 Jan;38(1):69-78. 10.3344/kjp.24314.

Perceptions of treatment, accompanying symptoms, and other problems in patients with chronic pain: a multicenter cross-sectional study in Korea

Affiliations
  • 1Department of Anesthesiology and Pain Medicine, Konkuk University School of Medicine, Seoul, Korea
  • 2Department of Anesthesiology and Pain Medicine, Inje University Sanggye Paik Hospital, Seoul, Korea
  • 3Department of Anesthesiology and Pain Medicine, Hallym University Kangdong Sacred Heart Hospital, Seoul, Korea
  • 4Department of Anesthesiology and Pain Medicine, Jeong-clinic, Seoul, Korea
  • 5Department of Anesthesiology and Pain Medicine, Jeju National University School of Medicine, Jeju, Korea
  • 6Department of Anesthesiology and Pain Medicine, Hallym University Kangnam Sacred Heart Hospital, Seoul, Korea

Abstract

Background
Chronic pain significantly affects daily activities, mental health, and the interpersonal relationships of patients. Consequently, physicians use various treatments to manage pain. This study investigated the perceptions of treatment, accompanying symptoms, and other problems in patients with chronic pain.
Methods
The authors enrolled patients with chronic pain from 19 university hospitals in South Korea. Data was collected on age, gender, diagnosis, disease duration, severity of pain, perception of pain treatment, and accompanying symptoms or problems using an anonymous survey comprising 19 questions.
Results
In total, 833 patients with chronic pain completed the survey, and 257 (31.0%) and 537 (64.5%) patients expressed concerns about the potential adverse effects of medication and opioid addiction, respectively. Personality changes such as irritability or anger were the most frequent accompanying symptoms in 507 (63.8%) patients, followed by depression and sleep disturbance in 462 (58.1%) and 450 (54.5%) patients, respectively. Depression (P = 0.001) and anxiety (P = 0.029) were more common among women, whereas divorce (P = 0.016), family conflict (P < 0.001), unemployment (P < 0.001), suicide attempts (P < 0.001), and restrictions on economic activity (P < 0.001) were more common among men. The frequency of accompanying symptoms, except for suicidal ideation, was higher in the younger patients aged ≤ 40 years than in the older patients aged > 40 years.
Conclusions
Many patients with chronic pain had concerns about adverse effects or medication tolerance and experienced anxiety, depression, or sleep disturbances. The prevalence of accompanying problems varies according to age and gender.

Keyword

Analgesics, Opioid; Anxiety; Chronic Pain; Depression; Nerve Block; Neuralgia; Psychosocial Functioning; Spinal Diseases; Treatment Outcome

Figure

  • Fig. 1 Proportions of patients according to the diagnosis. MPS: myofascial pain syndrome.

  • Fig. 2 Perception about pain medication among participants. S/E: side effect.

  • Fig. 3 Opinion about nerve block among participants.

  • Fig. 4 Prevalence of the accompanying problems among participants.

  • Fig. 5 Prevalence of suicidal ideation and suicidal attempts among participants.

  • Fig. 6 Prevalence of difficulties with people around them because of pain among participants.


Reference

1. Raja SN, Carr DB, Cohen M, Finnerup NB, Flor H, Gibson S, et al. 2020; The revised International Association for the Study of Pain definition of pain: concepts, challenges, and compromises. Pain. 161:1976–82. DOI: 10.1097/j.pain.0000000000001939. PMID: 32694387. PMCID: PMC7680716.
Article
2. Tang NK, Crane C. 2006; Suicidality in chronic pain: a review of the prevalence, risk factors and psychological links. Psychol Med. 36:575–86. DOI: 10.1017/S0033291705006859. PMID: 16420727.
Article
3. Breivik H, Collett B, Ventafridda V, Cohen R, Gallacher D. 2006; Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment. Eur J Pain. 10:287–333. DOI: 10.1016/j.ejpain.2005.06.009. PMID: 16095934.
Article
4. Nahm FS. 2024; Increasing opioid prescription in Korea: a pressing public health concern and necessitating initiatives. Korean J Pain. 37:1–2. DOI: 10.3344/kjp.23349. PMID: 38155107. PMCID: PMC10764210.
Article
5. Kim CL, Hong SJ, Lim YH, Jeong JH, Moon HS, Choi HR, et al. 2020; Patients' perception about opioids and addiction in South Korea. Korean J Pain. 33:234–44. DOI: 10.3344/kjp.2020.33.3.234. PMID: 32606268. PMCID: PMC7336346.
Article
6. Rosser BA, McCracken LM, Velleman SC, Boichat C, Eccleston C. 2011; Concerns about medication and medication adherence in patients with chronic pain recruited from general practice. Pain. 152:1201–5. DOI: 10.1016/j.pain.2011.01.053. PMID: 21376463.
Article
7. Shin BM, Hong SJ, Lim YH, Jeong JH, Moon HS, Choi HR, et al. 2019; A survey of patients' perspectives of steroid injection (ppyeojusa) in Korea. Korean J Pain. 32:187–95. DOI: 10.3344/kjp.2019.32.3.187. PMID: 31257827. PMCID: PMC6615452.
Article
8. Langeveld HR, Klitsie P, Smedinga H, Eker H, Van't Riet M, Weidema W, et al. 2015; Prognostic value of age for chronic postoperative inguinal pain. Hernia. 19:549–55. DOI: 10.1007/s10029-014-1282-0. PMID: 25092408.
Article
9. Klang E, Lidar M, Lidar Z, Aharoni D, Eshed I. 2017; Prevalence and awareness of sacroiliac joint alterations on lumbar spine CT in low back pain patients younger than 40 years. Acta Radiol. 58:449–55. DOI: 10.1177/0284185116656490. PMID: 27445315.
Article
10. Wettstein M, Eich W, Bieber C, Tesarz J. 2019; Pain intensity, disability, and quality of life in patients with chronic low back pain: does age matter? Pain Med. 20:464–75. DOI: 10.1093/pm/pny062. PMID: 29701812. PMCID: PMC6387985.
Article
11. McCracken LM, Hoskins J, Eccleston C. 2006; Concerns about medication and medication use in chronic pain. J Pain. 7:726–34. DOI: 10.1016/j.jpain.2006.02.014. PMID: 17018333.
Article
12. Timmerman L, Stronks DL, Huygen FJ. 2019; The relation between patients' beliefs about pain medication, medication adherence, and treatment outcome in chronic pain patients: a prospective study. Clin J Pain. 35:941–7. DOI: 10.1097/AJP.0000000000000760. PMID: 31513057.
13. Edlund MJ, Martin BC, Russo JE, DeVries A, Braden JB, Sullivan MD. 2014; The role of opioid prescription in incident opioid abuse and dependence among individuals with chronic noncancer pain: the role of opioid prescription. Clin J Pain. 30:557–64. DOI: 10.1097/AJP.0000000000000021. PMID: 24281273. PMCID: PMC4032801.
14. Kaye AD, Jones MR, Kaye AM, Ripoll JG, Galan V, Beakley BD, et al. 2017; Prescription opioid abuse in chronic pain: an updated review of opioid abuse predictors and strategies to curb opioid abuse: part 1. Pain Physician. 20:S93–109. DOI: 10.36076/ppj.2017.s109.
15. Dowell D, Ragan KR, Jones CM, Baldwin GT, Chou R. 2022; CDC clinical practice guideline for prescribing opioids for pain - United States, 2022. MMWR Recomm Rep. 71:1–95. DOI: 10.15585/mmwr.rr7103a1. PMID: 36327391. PMCID: PMC9639433.
Article
16. Oh TK, Jeon YT, Choi JW. 2019; Trends in chronic opioid use and association with five-year survival in South Korea: a population-based cohort study. Br J Anaesth. 123:655–63. DOI: 10.1016/j.bja.2019.08.012. PMID: 31558315.
Article
17. Kim MJ, Kim JY, Lim YH, Hong SJ, Jeong JH, Choi HR, et al. 2022; Actual situation and prescribing patterns of opioids by pain physicians in South Korea. Korean J Pain. 35:475–87. DOI: 10.3344/kjp.2022.35.4.475. PMID: 36175347. PMCID: PMC9530690.
Article
18. Kim ED, Lee JY, Son JS, Byeon GJ, Yeo JS, Kim DW, et al. Opioids Research Group in the Korean Pain Society. 2017; Guidelines for prescribing opioids for chronic non-cancer pain in Korea. Korean J Pain. 30:18–33. DOI: 10.3344/kjp.2017.30.1.18. PMID: 28119768. PMCID: PMC5256264.
Article
19. Kim M, Park SK, Kim WM, Kim E, Kim H, Park JM, et al. 2024; Updated guidelines for prescribing opioids to treat patients with chronic non-cancer pain in Korea: developed by committee on hospice and palliative care of the Korean Pain Society. Korean J Pain. 37:119–31. DOI: 10.3344/kjp.24022. PMID: 38557654. PMCID: PMC10985489.
Article
20. Zis P, Daskalaki A, Bountouni I, Sykioti P, Varrassi G, Paladini A. 2017; Depression and chronic pain in the elderly: links and management challenges. Clin Interv Aging. 12:709–20. DOI: 10.2147/CIA.S113576. PMID: 28461745. PMCID: PMC5407450.
Article
21. Elbinoune I, Amine B, Shyen S, Gueddari S, Abouqal R, Hajjaj-Hassouni N. 2016; Chronic neck pain and anxiety-depression: prevalence and associated risk factors. Pan Afr Med J. 24:89. DOI: 10.11604/pamj.2016.24.89.8831. PMID: 27642428. PMCID: PMC5012832.
Article
22. Fishbain DA, Lewis JE, Gao J. 2014; The pain suicidality association: a narrative review. Pain Med. 15:1835–49. DOI: 10.1111/pme.12463. PMID: 24995953.
Article
23. Kim SH, Sun JM, Yoon KB, Moon JH, An JR, Yoon DM. 2015; Risk factors associated with clinical insomnia in chronic low back pain: a retrospective analysis in a university hospital in Korea. Korean J Pain. 28:137–43. DOI: 10.3344/kjp.2015.28.2.137. PMID: 25852836. PMCID: PMC4387459.
Article
24. Lobbezoo F, Visscher CM, Naeije M. 2004; Impaired health status, sleep disorders, and pain in the craniomandibular and cervical spinal regions. Eur J Pain. 8:23–30. DOI: 10.1016/S1090-3801(03)00061-2. PMID: 14690671.
Article
25. Lee J, Lim YH, Hong SJ, Jeong JH, Choi HR, Park SK, et al. 2021; Multicenter survey of symptoms, work life, economic status, and quality of life of complex regional pain syndrome patients. Korean J Pain. 34:288–303. DOI: 10.3344/kjp.2021.34.3.288. PMID: 34193635. PMCID: PMC8255153.
Article
26. Dahlhamer J, Lucas J, Zelaya C, Nahin R, Mackey S, DeBar L, et al. 2018; Prevalence of chronic pain and high-impact chronic pain among adults - United States, 2016. MMWR Morb Mortal Wkly Rep. 67:1001–6. DOI: 10.15585/mmwr.mm6736a2. PMID: 30212442. PMCID: PMC6146950.
Article
27. KOSIS. Economically active population survey [Internet]. Daejeon: Statistics Korea;. Available at: https://kosis.kr/statHtml/statHtml.do?orgId=101&tblId=DT_1DA7001S&conn_path=I2.
28. Barry DT, Pilver CE, Hoff RA, Potenza MN. 2013; Pain interference and incident mood, anxiety, and substance-use disorders: findings from a representative sample of men and women in the general population. J Psychiatr Res. 47:1658–64. DOI: 10.1016/j.jpsychires.2013.08.004. PMID: 23992771. PMCID: PMC3835154.
Article
29. Lumley S, Yu D, Wilkie R, Jordan KP, Peat G. 2024; Chronic pain-mental health comorbidity and excess prevalence of health risk behaviours: a cross-sectional study. Prim Health Care Res Dev. 25:e15. DOI: 10.1017/S1463423624000070. PMID: 38587013. PMCID: PMC11022513.
Article
30. Murray CB, Patel KV, Twiddy H, Sturgeon JA, Palermo TM. 2021; Age differences in cognitive-affective processes in adults with chronic pain. Eur J Pain. 25:1041–52. DOI: 10.1002/ejp.1725. PMID: 33405280. PMCID: PMC8055045.
Article
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