Clin Mol Hepatol.
2025 Jan;31(1):56-73. 10.3350/cmh.2024.0782.
Bioactive metabolites: A clue to the link between MASLD and CKD?
- Affiliations
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- 1MAFLD Research Center, Department of Hepatology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
- 2Department of Pediatric Laboratory, Affiliated Children’s Hospital of Jiangnan University, Wuxi Children’s Hospital, Wuxi, Jiangsu, China
- 3Southampton National Institute for Health and Care Research Biomedical Research Centre, University Hospital Southampton and University of Southampton, Southampton General Hospital, Southampton, UK
- 4Department of Medicine, University of Verona, Verona, Italy
- 5Metabolic Diseases Research Unit, IRCCS Sacro Cuore - Don Calabria Hospital, Negrar di Valpolicella, Italy
- 6Intensive Care Medicine, Jiangnan University Medical Center, Wuxi, China
- 7Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China
- 8Institute of Hepatology, Wenzhou Medical University, Wenzhou, China
- 9Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province, Wenzhou, China
- 10Urologic Nephrology Center, Jiangnan University Medical Center, Wuxi, China
- 11Affiliated Wuxi Clinical College of Nantong University, Wuxi, China
- 12Department of Nephrology, Wuxi No.2 People’s Hospital, Wuxi, China
- KMID: 2563407
- DOI: http://doi.org/10.3350/cmh.2024.0782
Abstract
- Metabolites produced as intermediaries or end-products of microbial metabolism provide crucial signals for health and diseases, such as metabolic dysfunction-associated steatotic liver disease (MASLD). These metabolites include products of the bacterial metabolism of dietary substrates, modification of host molecules (such as bile acids [BAs], trimethylamine-N-oxide, and short-chain fatty acids), or products directly derived from bacteria. Recent studies have provided new insights into the association between MASLD and the risk of developing chronic kidney disease (CKD). Furthermore, alterations in microbiota composition and metabolite profiles, notably altered BAs, have been described in studies investigating the association between MASLD and the risk of CKD. This narrative review discusses alterations of specific classes of metabolites, BAs, fructose, vitamin D, and microbiota composition that may be implicated in the link between MASLD and CKD.
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