Int J Oral Biol.  2024 Jun;49(2):34-41. 10.11620/IJOB.2024.49.2.34.

Secretagogin deficiency causes abnormal extracellular trap formation in microglia

• Kim YG
• Kim DY

• KMID: 2562644
• DOI: http://doi.org/10.11620/IJOB.2024.49.2.34

Abstract

Extracellular traps (ETs), primarily composed of DNA and antibacterial peptides, are mainly secreted by neutrophils to inhibit pathogen spread and eliminate microorganisms. Recent reports suggest that microglia can also secrete ETs, and these microglial ETs are associated with various neurological conditions, including nerve injury, tumor microenvironment, and ischemic stroke. However, the components and functions of microglial ETs remain underexplored. Secretagogin (Scgn), a calcium-sensor protein, plays a crucial role in the release of peptide hormones, such as insulin, in endocrine cells; however, its function in immune cells, including microglia, is not well understood. Our study demonstrated that Scgn deficiency can lead to the formation of abnormal ETs. We hypothesized that this may involve the c-Jun N-terminal kinase-myeloperoxidase pathway and autophagy.

Keyword

Microglia; Secretagogins; Extracellular traps; Oxidative stress