J Med Life Sci.
2022 Dec;19(3):130-133. 10.22730/jmls.2022.19.3.130.
Neuromyelitis optica spectrum disorders with an inverted V sign on spinal cord magnetic resonance imaging: antiaquaporin-4 antibody and functional vitamin B12 deficiency
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- 1Department of Neurology, Keimyung University School of Medicine, Daegu, Republic of Korea
- KMID: 2561918
- DOI: http://doi.org/10.22730/jmls.2022.19.3.130
Abstract
- Several studies have reported a possible link between antiaquaporin- 4 antibody and vitamin B12 deficiency in neuromyelitis optica spectrum disorder (NMOSD). Bilaterally symmetric hyperintense signals on magnetic resonance imaging (MRI) of the posterior columns, called the inverted V sign, are a characteristic feature of subacute combined degeneration associated with vitamin B12 deficiency. We report a patient with anti-aquaporin-4 antibodypositive NMOSD and an inverted V sign on MRI of the spinal cord and address the association between anti-aquaporin-4 antibody and functional vitamin B12 deficiency.
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