Ann Liver Transplant.  2021 Nov;1(2):135-139. 10.52604/alt.21.0026.

Analysis of nationwide volume of liver transplantation in Korea during 2020 shows no definitive decrease during COVID-19 outbreak

• Chung YK
• Kang SH

• KMID: 2560863
• DOI: http://doi.org/10.52604/alt.21.0026

Abstract

Background
Recent outbreak of Coronavirus disease 2019 (COVID-19) has discouraged organ donation. To determine its impact on liver transplantation (LT) at Korean transplant centers, it is necessary to analyze the incidence and type of LT in each center.
Methods
The number of deceased donor LT (DDLT) and living donor LT (LDLT) operations performed during the year 2020 were analyzed using the Korean Network for Organ Sharing (KONOS) database.
Results
During the 21-year period from 2000 to 2020, the total number of all deceased organ donors was 6,064 and 5,252 cases of DDLT were performed. The deceased donor and DDLT case numbers were 450 and 391, respectively, in the year 2019, and 478 and 395, respectively, in the year 2020 (p=0.284). The mean number of monthly DDLT was 32.6±5.7 in 2019 and 32.9±4.7 in 2020 (p=0.877). The case numbers of DDLT and LDLT in 2020 were 395 and 1,221, respectively. Forty-one centers performed both DDLT and LDLT, but five centers performed only DDLT and another 10 centers performed only LDLT. The five major LT centers performed 974 cases, which accounted for 60.3% of nation-wide LT volume in 2020, including 45.3% of DDLT and 65.1% of LDLT.
Conclusion
The results of this study suggested that national activities of DDLT and LDLT remained stable in Korea in the year 2020, despite of the ongoing COVID-19 pandemic. Further follow-up studies are necessary to validate the results of this study.

Keyword

Coronavirus disease 19; Deceased donor; Living donor; Immunosuppression; Donation promotion

Figure

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  Figure 1 Comparison of nationwide monthly number of deceased donors (A) and deceased donor liver transplantations (DDLT; B) in Korea between the years 2019 and 2020.

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  Figure 2 Nationwide annual number of deceased donors and deceased donor liver transplantation (DDLT) in Korea between the year 2000 and 2020.

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  Figure 3 Distribution of recipient age according to deceased donor liver transplantation (DDLT) and living donor liver transplantation (LDLT) in 2020.

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  Figure 4 Distribution of Korean transplantation centers performing deceased donor liver transplantation (DDLT) and living donor liver transplantation (LDLT) in 2020. LT, liver transplantation.

Reference

1. Lee SG, Moon DB, Hwang S, Ahn CS, Kim KH, Song GW, et al. 2015; Liver transplantation in Korea: past, present, and future. Transplant Proc. 47:705–708. DOI: 10.1016/j.transproceed.2015.02.015.

2. Lee JG, Lee KW, Kwon CHD, Chu CW, Kim BW, Choi DL, et al. 2017; Donor safety in living donor liver transplantation: the Korean organ transplantation registry study. Liver Transpl. 23:999–1006. DOI: 10.1002/lt.24778.

3. Hwang S, Ha TY, Ahn CS, Moon DB, Kim KH, Song GW, et al. 2016; Standardized surgical techniques for adult living donor liver transplantation using a modified right lobe graft: a video presentation from bench to reperfusion. Korean J Hepatobiliary Pancreat Surg. 20:97–101. DOI: 10.14701/kjhbps.2016.20.3.97.

4. Min SI, Ahn C, Han DJ, Kim SI, Chung SY, Lee SK, et al. 2015; To achieve national self-sufficiency: recent progresses in deceased donation in Korea. Transplantation. 99:765–770. DOI: 10.1097/TP.0000000000000412.

5. Gori A, Dondossola D, Antonelli B, Mangioni D, Alagna L, Reggiani P, et al. 2020; Coronavirus disease 2019 and transplantation: a view from the inside. Am J Transplant. 20:1939–1940. DOI: 10.1111/ajt.15853.

6. Michaels MG, La Hoz RM, Danziger-Isakov L, Blumberg EA, Kumar D, Green M, et al. 2020; Coronavirus disease 2019: implications of emerging infections for transplantation. Am J Transplant. 20:1768–1772. DOI: 10.1111/ajt.15832.

7. Angelico R, Trapani S, Manzia TM, Lombardini L, Tisone G, Cardillo M. 2020; The COVID-19 outbreak in Italy: initial implications for organ transplantation programs. Am J Transplant. 20:1780–1784. DOI: 10.1111/ajt.15904.

8. Boyarsky BJ, Po-Yu Chiang T, Werbel WA, Durand CM, Avery RK, Getsin SN, et al. 2020; Early impact of COVID-19 on transplant center practices and policies in the United States. Am J Transplant. 20:1809–1818. DOI: 10.1111/ajt.15915.

9. Kumar D, Manuel O, Natori Y, Egawa H, Grossi P, Han SH, et al. 2020; COVID-19: a global transplant perspective on successfully navigating a pandemic. Am J Transplant. 20:1773–1779. DOI: 10.1111/ajt.15876.

10. Columbia University Kidney Transplant Program. 2020; Early description of coronavirus 2019 disease in kidney transplant recipients in New York. J Am Soc Nephrol. 31:1150–1156. DOI: 10.1681/ASN.2020030375.

11. Lee J, Kim EJ, Ihn K, Lee JG, Joo DJ, Kim MS, et al. 2020; The feasibility of organ transplantation during the COVID-19 outbreak: experiences from South Korea. Korean J Transplant. 34:257–264. DOI: 10.4285/kjt.20.0048.

12. Forns X, Navasa M. 2020; Liver transplant immunosuppression during the COVID-19 pandemic. Gastroenterol Hepatol. 43:457–463. DOI: 10.1016/j.gastrohep.2020.06.003.

13. Ha HS, Hong JJ, Kim IO, Lee SR, Lee AY, Ha TY, et al. 2019; Deceased donor liver transplantation under the Korean model for end-stage liver disease score-based liver allocation system: 2-year allocation results at a high-volume transplantation center. Korean J Transplant. 33:112–117. DOI: 10.4285/jkstn.2019.33.4.112.

14. Heo SJ, Ju YH, Noh EJ, Kim KM, Son YK, Jung SW, et al. 2021; A study on the performance of the donation improvement program in Korea. Korean J Transplant. 35:77–85. DOI: 10.4285/kjt.21.0006.