J Gastric Cancer.
2024 Oct;24(4):378-390. 10.5230/jgc.2024.24.e30.
Oxyntic Gland Neoplasms - From Adenoma to Advanced Gastric Cancer: A Review of 29 Cases
- Affiliations
-
- 1Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
- 2Department of Pathology, Central Draft Physical Examination Office, Military Manpower Administration, Daegu, Korea
- 3Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
- 4Division of Gastroenterology, Department of Internal Medicine, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Korea
- KMID: 2560583
- DOI: http://doi.org/10.5230/jgc.2024.24.e30
Abstract
- Purpose
Oxyntic gland neoplasm (OGN) is a rare condition that can be classified as oxyntic gland adenoma (OGA) or gastric adenocarcinoma of fundic-gland type (GA-FG). GA-FG primarily presents as early gastric cancer, with only a few reported cases of advanced gastric cancer (AGC). We aimed to investigate the clinicopathological features of OGN and describe an aggressive variant.
Materials and Methods
We investigated a total of 29 cases, including a patient with double primary cases, diagnosed with OGN or differentiated-type adenocarcinoma with GA-FG morphology, between November 2016 and April 2022. We analyzed 54 pathological specimens and reviewed their clinicopathological, endoscopic, and histological features. The lesions were reclassified as OGA or GA-FG, and immunohistochemical (IHC) staining for MUC-5AC and MUC-6 was performed on available resected GA-FG cases.
Results
The median patient age was 65 years and males accounted for 58.6% of patients. Most cases occurred in the body horizontally (69.0%) and on the greater curvature side cross-sectionally (48.3%). Endoscopically, type 0-IIa (41.4%) and a subepithelial tumor-like appearance (24.1%) were the most common findings. Histologically, there were 8 cases of OGA (27.6%) and 21 cases of GA-FG (72.4%). In GA-FG, MUC-6 was positive in 13 cases (81.3%), whereas MUC-5AC was positive in 8 cases (50.0%). Three cases presented as AGCs.
Conclusions
Although OGNs are generally considered low-grade, they can present as AGCs and may exhibit features of lymphovascular or perineural invasion. Recognizing the clinicopathological features and accurately diagnosing OGN are important for providing adequate treatment.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Oxyntic Gland Adenoma Treated by Endoscopic Mucosal Resection
- Regression of colorectal adenoma
- Gastric Polyps and Protruding Type Gastric Cancer
- Follow-up of endoscopic mucosal resection for gastric adenoma and early gastric cancer
- Oxyntic Gland Area and Density of Parietal Cells and Its Relationship to Acid Output in Helicobacter pylori Infected Duodenal Ulcer Patients
