J Wound Manag Res.  2024 Oct;20(3):225-233. 10.22467/jwmr.2024.03104.

Evaluating the Role of Hyperbaric Oxygenation Therapy in Improving Diabetic Foot Ulcer Healing: A Systematic Review

• Martina NR
• Margareth SA
• Putri MYU
• Harlim C
• Kuswandi W

• KMID: 2560422
• DOI: http://doi.org/10.22467/jwmr.2024.03104

Abstract

Background
Diabetic foot ulcer (DFU) is a frequent complication of poorly controlled diabetes mellitus and can lead to amputation, significantly impacting quality of life. Although DFU is common, its treatment remains complex and could benefit from improvement. Hyperbaric oxygenation therapy (HBOT) is a noninvasive procedure that has recently shown potential as an alternative treatment for DFU. Given the increasing interest in HBOT, with many centers actively researching and developing advancements in this area, this review aims to not only gather and analyze relevant studies but also assess the feasibility of integrating HBOT into clinical practice as a viable, noninvasive alternative for DFU treatment.
Methods
This review was conducted following the 2020 Preferred Reporting Items for Systematic Review and Meta-Analysis guideline on studies published on HBOT for DFU. Each included study was critically appraised using the 2020 JBI Checklist for Randomized Controlled Trials.
Results
From three databases, eight out of 1,665 records were included for this review. Critical appraisal revealed that of the eight studies, only three fulfilled all criteria outlined in the checklist, as three studies did not indicate blinding, and two studies were open-label. The utilization of HBOT in the treatment of DFU resulted in various changes both in the wound healing process and risk of complications.
Conclusion
Based on the majority of the included studies, HBOT revealed a positive impact in aiding the healing of DFUs and in mitigating various risk of complications.

Keyword

Hyperbaric oxygenation; Diabetic foot; Ulcer; Effectiveness; Therapeutics