Biomol Ther.
2024 Sep;32(5):556-567. 10.4062/biomolther.2024.047.
Investigating the Immune-Stimulating Potential of β-Glucan from Aureobasidium pullulans in Cancer Immunotherapy
- Affiliations
-
- 1Department of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea
- 2KNU Researcher training program for Innovative Drug Development Research Team for Intractable Diseases (BK21 plus), Kangwon National University, Chuncheon 24341, Republic of Korea
- 3Global/Gangwon Innovative Biologics-Regional Leading Research Center (GIB-RLRC), Kangwon National University, Chuncheon 24341, Republic of Korea
- 4Institute of Agricultural Science and Technology, Chonnam National University, Gwangju 61186, Republic of Korea
- 5Department of Integrative Food, Bioscience and Biotechnology, Chonnam National University, Gwangju 61186, Republic of Korea
- 6Nodcure, Inc., Gwangju 61186, Republic of Korea
- 7Laboratory Animal Medicine, Animal Medical Institute, College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Republic of Korea
- KMID: 2559245
- DOI: http://doi.org/10.4062/biomolther.2024.047
Abstract
- β-glucan, a polysaccharide found in various sources, exhibits unique physicochemical properties, yet its high polymerization limits clinical applications because of its solubility. Addressing this limitation, we introduce PPTEE-glycan, a highly purified soluble β-1,3/1,6-glucan derived from Aureobasidium pullulans. The refined PPTEE-glycan demonstrated robust immune stimulation in vitro, activated dendritic cells, and enhanced co-stimulatory markers, cytokines, and cross-presentation. Formulated as a PPTEE + microemulsion (ME), it elevated immune responses in vivo, promoting antigen-specific antibodies and CD8+ T cell proliferation. Intratumoral administration of PPTEE + ME in tumor-bearing mice induced notable tumor regression, which was linked to the activation of immunosuppressive cells. This study highlights the potential of high-purity Aureobasidium pullulans-derived β-glucan, particularly PPTEE, as promising immune adjuvants, offering novel avenues for advancing cancer immunotherapy.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- A Case of Onychomycosis due to Aureobasidium pullulans after Trauma
- Recent Advances in Immunotherapy of Lung Cancer
- Current Development Status of Cytokines for Cancer Immunotherapy
- Cancer Immunotherapy: The Dawn of the Renaissance after the Medieval Dark Ages
- Stimulatory Effect of beta-glucans on Immune Cells
