Immune Netw.  2024 Jun;24(3):e23. 10.4110/in.2024.24.e23.

Neutrophil Migration Is Mediated by VLA-6 in the Inflamed Adipose Tissue

• Lim H
• Choe YH
• Lee J
• Kim GE
• Hyun JW
• Hyun YM

• KMID: 2557909
• DOI: http://doi.org/10.4110/in.2024.24.e23

Abstract

Adipose tissue, well known for its endocrine function, plays an immunological role in the body. The inflamed adipose tissue under LPS-induced systemic inflammation is characterized by the dominance of pro-inflammatory immune cells, particularly neutrophils. Although migration of macrophages toward damaged or dead adipocytes to form a crownlike structure in inflamed adipose tissue has been revealed, the neutrophilic interaction with adipocytes or the extracellular matrix remains unknown. Here, we demonstrated the involvement of adhesion molecules, particularly integrin α6β1, of neutrophils in adipocytes or the extracellular matrix of inflamed adipose tissue interaction. These results suggest that disrupting the adhesion between adipose tissue components and neutrophils may govern the accumulation of excessive neutrophils in inflamed tissues, a prerequisite in developing antiinflammatory therapeutics by inhibiting inflammatory immune cells.

Keyword

Two-photon microscopy; Adipose tissue; Neutrophil; Integrin