Osteoporos Sarcopenia.  2024 Jun;10(2):54-59. 10.1016/j.afos.2024.03.001.

Regional variation in bone mineral density of the distal radius

• Morgan H
• Knight K
• Meertens R

• KMID: 2557455
• DOI: http://doi.org/10.1016/j.afos.2024.03.001

Abstract

Objectives
This study investigates the regional variation in areal bone mineral density (aBMD) at the distal radius, a critical site for osteoporosis-related fractures. Understanding aBMD distribution is essential for accurate diagnosis and management of osteoporosis.
Methods
The study involved 261 participants aged over 50. Using dual-energy X-ray absorptiometry (DXA) scans, aBMD was recorded across contiguous regions of the distal radius. Factors considered include age, sex, and hand dominance, providing a comprehensive view of aBMD distribution.
Results
The findings indicated a consistent pattern in aBMD distribution along the radius, with a plateau around the one-third distance from the wrist. Notably, significant differences in aBMD were observed between age groups, especially among post-menopausal women. The study also recorded minor variations in aBMD between dominant and non-dominant forearms.
Conclusions
The study’s insights into aBMD variation at the distal radius have implications for osteoporosis research and clinical diagnosis. It highlights the importance of standardized region of interest placement in DXA scans for accurate assessment.

Keyword

Dual-energy X-ray absorptiometry; Forearm; Osteoporosis; Sex-based differences; Hand dominance