Ann Coloproctol.  2024 Apr;40(2):161-168. 10.3393/ac.2022.00367.0052.

Evaluating prognostic significance of preoperative C-reactive protein to albumin ratio in older patients with pathological stage II or III colorectal cancer

• Numata K
• Ono Y
• Ju M
• Onuma S
• Tanaka A
• Kawabe T
• Sawazaki S
• Higuchi A
• Yamanaka K
• Hatori S
• Saeki H
• Matsukawa H
• Rino Y
• Tani K

• KMID: 2556082
• DOI: http://doi.org/10.3393/ac.2022.00367.0052

Abstract

Purpose
This study was performed to evaluate the prognostic value of preoperative C-reactive protein to albumin ratio (CAR) in older patients with colorectal cancer (CRC) undergoing curative resection.
Methods
We retrospectively analyzed 244 older patients (aged 75 years or higher) with pathological stage II or III CRC who underwent curative surgery between 2008 and 2016. The optimal value of CAR was calculated and its correlation with the clinicopathological factors and prognosis was examined.
Results
The optimal cutoff value of the CAR was 0.085. High preoperative CAR was significantly associated with high carcinoembryonic antigen levels (P=0.001), larger tumor size (P<0.001), and pT factor (P=0.001). On multivariate analysis, high CAR was independent prognostic factor for relapse-free survival (P=0.042) and overall survival (P=0.001).
Conclusion
Preoperative elevated CAR could be considered as an adverse predictor of both relapse-free survival and overall survival in older patients with CRC undergoing curative surgery.

Keyword

Colorectal neoplasms; Curative surgery; Older patients; C-reactive protein to albumin ratio; Prognosis