J Lipid Atheroscler.  2024 May;13(2):89-96. 10.12997/jla.2024.13.2.89.

The Effect of Omega-3 Supplementation on Heart Failure Outcome: A Meta-Analysis of Randomized Clinical Trial

• Dwiputra B
• Ambari AM
• Desandri DR
• Purwowiyoto BS
• Radi B
• Pandhita BAW
• Fatrin S
• Santoso A

• KMID: 2556018
• DOI: http://doi.org/10.12997/jla.2024.13.2.89

Abstract

The effect of omega-3 supplementation on cardiovascular (CV) disease has been widely studied in several large clinical trials. However, the evidence of the effect of omega-3 supplementation in patients with heart failure (HF) remains controversial. This meta-analysis investigated the effects of omega-3 supplementation on patients with HF. We conducted a literature search on MEDLINE, Embase, and Cochrane databases for clinical trials and preprints of relevant articles. Following a literature search and critical appraisal, 5 studies were included in the meta-analysis. The pooling of the result of the studies shows that there were no significant association between omega-3 supplementation and CV mortality (odds ratio [OR], 0.94; 95% confidence interval [CI], 0.84–1.05, p=0.16) nor hospitalization due to HF (OR, 0.94; 95% CI, 0.88–1.02; p=0.13). Our systematic review and meta-analysis showed that omega-3 supplementation has no beneficial effect in patients with HF.

Keyword

Atherosclerosis; Cardiovascular disease; Omega-3 fatty acid; Secondary prevention