Gut Liver.  2024 May;18(3):391-403. 10.5009/gnl220346.

Research Progress of Central and Peripheral CorticotropinReleasing Hormone in Irritable Bowel Syndrome with Comorbid Dysthymic Disorders

Affiliations
  • 1College of Acupuncture and Massage, Anhui University of Chinese Medicine, Hefei, China
  • 2College of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, China

Abstract

Irritable bowel syndrome (IBS) is considered a stress disorder characterized by psychological and gastrointestinal dysfunction. IBS patients not only suffer from intestinal symptoms such as abdominal pain, diarrhea, or constipation but also, experience dysthymic disorders such as anxiety and depression. Studies have found that corticotropin-releasing hormone plays a key role in IBS with comorbid dysthymic disorders. Next, we will summarize the effects of corticotropinreleasing hormone from the central nervous system and periphery on IBS with comorbid dysthymic disorders and relevant treatments based on published literatures in recent years.

Keyword

Irritable bowel syndrome; Dysthymic disorder; Corticotropin-releasing hormone; Review
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