J Neurogastroenterol Motil.
2024 Apr;30(2):194-207. 10.5056/jnm23184.
The Effects of Fermented Rice Drink With Lactiplantibacillus plantarum JSA22 in Overweight Irritable Bowel Syndrome Patients: A Randomized, Double-blind, Placebo-controlled Study
- Affiliations
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- 1Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
- 2National Institute of Crop Science, Rural Development Administration, Suwon, Gyeonggi-do, Korea
- 3Digestive Diseases Research Institute, School of Medicine, Wonkwang University, Iksan, Jeollabuk-do, Korea
- 4Department of Food Science and Technology, Chungbuk National University, Cheongju, Chungcheongbuk-do, Korea
- 5Endomics, Inc, Seongnam, Gyeonggi-do, Korea; and 6 Gut & Food Healthcare Co, Ltd, Seongnam, Gyeonggi-do, Korea
- KMID: 2555202
- DOI: http://doi.org/10.5056/jnm23184
Abstract
- Background/Aims
This study aims to investigate the effect of a fermented rice drink with Lactiplantibacillus plantarum JSA22 on symptoms, blood tests, microbiomes, and fecal metabolites in patients with irritable bowel syndrome (IBS) who were overweight.
Methods
Sixty overweight (body mass index ≥ 23 kg/m2 ) patients aged between 20 and 65 with IBS were enrolled. Patients were divided into 2 groups and administered either a fermented rice drink or an nonfermented rice drink for a month. The symptom questionnaire, blood samples, and stool samples for microbiome and metabolite were collected before and after the month of rice drink administration. The primary efficacy variable was the subject’s global assessment of IBS symptoms.
Results
In both groups, global IBS symptoms, including abdominal pain, bowel habit, urgency, and abdominal distension, improved significantly (P < 0.01). The abdominal bloating was more significantly improved in the fermented rice drink group than in the nonfermented rice drink group (P < 0.05). Significant changes were not observed in metabolic syndrome-related blood tests or fecal metabolites in either group. However, microbiome analysis showed significant differences in genus levels before and after consuming fermented rice drink, such as in Blautia in stool (P = 0.020) and Prevotella (P = 0.017) and Oribacterium (P = 0.018) in saliva.
Conclusions
The fermented rice drink with L. plantarum JSA22 showed a beneficial effect in reducing abdominal distension in IBS patients. Bacteria that reduce visceral fat accumulation increased in the stool and saliva of patients who consumed fermented rice drinks.
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