J Neurointensive Care.  2021 Apr;4(1):36-41. 10.32587/jnic.2021.00353.

Clinical case of CNS-involved refractory thrombotic thrombocytopenic purpura

Affiliations
  • 1Department of Neurosurgery and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

Abstract

The thrombotic thrombocytopenic purpura (TTP) is not a common disease entity and presents multiple systemic symptoms, constellation of ambiguous GI complaints, fever, neurologic deficits and renal failure. As well as the mentioned symptoms, unexpected atypical symptoms related to small vessel occlusion could be complicated. In this case, multifocal cerebral infarction and non-territorial cardiac ischemia was noted. Surgery-related TTP is not common and needed to differentiate from surgery-related complications. We reported orthopedic surgery-related clinical vignette of TTP treated by plasmapheresis and the related literature would be reviewed.

Keyword

Thrombotic thrombocytopenic purpura; Cerebral infarction; Coronary artery; Plasmapheresis
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