Infect Chemother.
2024 Mar;56(1):57-65. 10.3947/ic.2023.0067.
Phage Therapy in Korea: A Prescribers' Survey of Attitudes Amongst Korean Infectious Diseases Specialists Towards Phage Therapy
- Lee S
1,2 - Lynch S2,3,4
- Lin RCY2,3,5
- Myung H6,7
- Iredell JR2,3,4
- Affiliations
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- 1Department of Internal Medicine, Pusan National University School of Medicine and Medical Research Institute, Pusan National University Hospital, Busan, Korea
- 2Centre for Infectious Diseases and Microbiology, Westmead Institute for Medical Research, Westmead, NSW, Australia
- 3Faculty of Medicine, The University of Sydney, Sydney, New South Wales, Australia
- 4Westmead Hospital, Western Sydney Local Health District, Sydney, New South Wales, Australia
- 5School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia
- 6Bioscience and Biotechnology, Hankuk University of Foreign Studies, Seoul, Korea
- 7LyseNTech, Co. Ltd. Seongnam, Korea
- KMID: 2554977
- DOI: http://doi.org/10.3947/ic.2023.0067
Abstract
- Background
Concerns about the rise in antimicrobial resistance have led to renewed interest in phage therapy worldwide, but perceptions among relevant medical professionals in Korea remain largely unknown.
Materials and Methods
We conducted a semi-quantitative online survey to evaluate the Korean infectious disease specialists' perception of phage therapy.
Results
We sent out the link to the questionnaire to 380 subjects and received 91 replies, with 90/91 respondents identifying as Korean infectious diseases specialists or trainees. Ten out of 91 (11.0%) respondents scored themselves as well-informed about phage therapy. The majority (93.4%) of respondents would consider using phage therapy if the safety of the phage formulation is guaranteed, and 80% of respondents would consider participating in clinical trials with phage therapy given adequate support. The biggest concern was uncertainty about safety (73.6%) and efficacy (65.9%). Acinetobacter baumannii was ranked as a high priority for phage therapy research, as were bone and joint infections.
Conclusion
Korean infectious diseases specialists are receptive to phage therapy, but a better understanding of safety, efficacy and clinical trials are warranted to progress phage therapy within the Korean healthcare system.
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