J Cerebrovasc Endovasc Neurosurg.  2024 Mar;26(1):58-64. 10.7461/jcen.2023.E2023.04.001.

Flow diverter stenting for intracranial aneurysms in the pediatric population: Two case reports and literature review

Affiliations
  • 1Department of Neurosurgery, Medical College of Wisconsin, WI, USA
  • 2Department of Neurology, Medical College of Wisconsin, Wauwatosa, WI, USA
  • 3Department of Neurosurgery, Northwell Health, New York, USA

Abstract

The Pipeline Embolization Device (PED) is a flow-diverting intraluminal device that is approved for use in adults 18 years or older with internal carotid artery aneurysms. However, it can also be used off-label in pediatric patients with aneurysms that cannot be resolved with traditional endovascular treatments. Herein, we present two cases of flow diversion in the pediatric population with complete obliteration of the aneurysm and excellent outcomes. Flow diversion has been shown to be a safe endovascular option in treating complex aneurysms in children. Larger-sized, multicenter trials are encouraged to compare outcomes between flow diversion and other aneurysm treatment options given the rarity of pediatric aneurysms.

Keyword

Pediatrics; Flow diversion; Intracranial aneurysms; Neurosurgery; Pipeline Embolization Device

Figure

  • Fig. 1. A 3D reconstruction angiogram reveals a dysplastic, fusiform, multilobular aneurysm measuring 11 mm×9 mm. 3D, threedimensional

  • Fig. 2. Six-month follow-up angiogram shows complete resolution of the left terminal ICA aneurysm and non-flow-limiting tapering stenosis of the left supraclinoid carotid. ICA, internal carotid artery

  • Fig. 3. A 3D reconstruction angiogram reveals a dysplastic segment of the left-sided supraclinoid ICA with a broad-based, saccular 6.2 mm aneurysm. 3D, three-dimensional; ICA, internal carotid artery

  • Fig. 4. Six-month follow-up angiogram shows complete thrombosis of the left ICA aneurysm. ICA, internal carotid artery


Reference

1. Abla AA, Zaidi HA, Crowley RW, Britz GW, McDougall CG, Albuquerque FC, et al. Optic chiasm compression from mass effect and thrombus formation following unsuccessful treatment of a giant supraclinoid ICA aneurysm with the Pipeline device: Open surgical bailout with STA-MCA bypass and parent vessel occlusion. J Neurosurg Pediatr. 2014; Jul. 14(1):31–7.
Article
2. Adeeb N, Griessenauer CJ, Foreman PM, Moore JM, Shallwani H, Motiei-Langroudi R, et al. Use of platelet function testing before pipeline embolization device placement: A multicenter cohort study. Stroke. 2017; May. 48(5):1322–30.
Article
3. Appelboom G, Kadri K, Hassan F, Leclerc X. Infectious aneurysm of the cavernous carotid artery in a child treated with a new-generation of flow-diverting stent graft: Case report. Neurosurgery. 2010; Mar. 66(3):e623–4. discussion e624.
4. Ares WJ, Tonetti DA, Greene S, Sharma MS, Xavier F, Jankowitz BT, et al. Pipeline embolization of an infectious basilar artery aneurysm in a 2-year-old child: Case report, discussion of the literature and perioperative considerations. Oper Neurosurg (Hagerstown). 2019; Nov. 17(5):e224–8.
Article
5. Barburoglu M, Arat A. Flow diverters in the treatment of pediatric cerebrovascular diseases. AJNR Am J Neuroradiol. 2017; Jan. 38(1):113–8.
Article
6. Burrows AM, Zipfel G, Lanzino G. Treatment of a pediatric recurrent fusiform middle cerebral artery (MCA) aneurysm with a flow diverter. J Neurointerv Surg. 2013; Nov. 5(6):e47.
Article
7. Cherian J, Srinivasan V, Froehler MT, Grossberg JA, Cawley CM, Hanel RA, et al. Flow diversion for treatment of intracranial aneurysms in pediatric patients: Multicenter case series. Neurosurgery. 2020; Jul. 87(1):53–62.
Article
8. Cinar C, Bozkaya H, Oran I. Endovascular treatment of cranial aneurysms with the pipeline flow diverting stent: Preliminary midterm results. Diagn Interv Radiol. 2013; MarApr. 19(2):154–64.
Article
9. Cobb MIH, Zomorodi AR, Hauck EF, Smith TP, Fernando Gonzalez L. Optimal pediatric dosing of anti-platelet agents for pipeline stent embolization: A case report and review of the literature. Childs Nerv Syst. 2017; Apr. 33(4):685–90.
Article
10. Colby GP, Jiang B, Bender MT, Beaty NB, Westbroek EM, Xu R, et al. Pipeline-assisted coil embolization of a large middle cerebral artery pseudoaneurysm in a 9-month-old infant: Experience from the youngest flow diversion case. J Neurosurg Pediatr. 2018; Nov. 22(5):532–40.
Article
11. Crowley RW, Evans AJ, Kassell NF, Jensen ME, Dumont AS. Endovascular treatment of a fusiform basilar artery aneurysm using multiple “in-stent stents”: Technical note. J Neurosurg Pediatr. 2009; Jun. 3(6):496–500.
Article
12. Cunegatto-Braga M, Hogan B, Aguilar-Salinas P, Beier AD, Hanel RA. Pipeline embolization device flow diversion for a dissecting ruptured posterior cerebral artery aneurysm in a pediatric patient. World Neurosurg. 2018; Sep. 117:255–60.
Article
13. de Barros Faria M, Castro RN, Lundquist J, Scrivano E, Ceratto R, Ferrario A, et al. The role of the pipeline embolization device for the treatment of dissecting intracranial aneurysms. AJNR Am J Neuroradiol. 2011; Dec. 32(11):2192–5.
Article
14. Eddleman CS, Surdell D, DiPatri A, Tomita T, Shaibani A. Infectious intracranial aneurysms in the pediatric population: Endovascular treatment with Onyx. Childs Nerv Syst. 2008; Aug. 24(8):909–15.
Article
15. Ghali MGZ, Srinivasan VM, Cherian J, Wagner KM, Chen SR, Johnson J, et al. Multimodal treatment of intracranial aneurysms in children: Clinical case series and review of the literature. World Neurosurg. 2018; Mar. 111:e294–307.
Article
16. Ikeda DS, Marlin ES, Shaw A, Powers CJ. Successful endovascular reconstruction of a recurrent giant middle cerebral artery aneurysm with multiple telescoping flow diverters in a pediatric patient. Pediatr Neurosurg. 2015; 50(2):88–93.
Article
17. Jia L, Wang J, Zhang L, Zhang Y, You W, Yang X, et al. Pediatric patient with a giant vertebrobasilar dissecting aneurysm successfully treated with three pipeline embolization devices. Front Neurol. 2020; Jul. 11:633.
Article
18. Kalani MY, Elhadi AM, Ramey W, Nakaji P, Albuquerque FC, McDougall CG, et al. Revascularization and pediatric aneurysm surgery. J Neurosurg Pediatr. 2014; Jun. 13(6):641–6.
Article
19. Kan P, Mokin M, Puri AS, Wakhloo AK. Successful treatment of a giant pediatric fusiform basilar trunk aneurysm with surpass flow diverter. J Neurointerv Surg. 2016; Jun. 8(6):e23.
Article
20. Kim M, Lee HS, Lee S, Park JC, Ahn JS, Kwon DH, et al. Pediatric intracranial aneurysms: Favorable outcomes despite rareness and complexity. World Neurosurg. 2019; May. 125:e1203–16.
Article
21. Krings T, Geibprasert S, terBrugge KG. Pathomechanisms and treatment of pediatric aneurysms. Childs Nerv Syst. 2010; Oct. 26(10):1309–18.
Article
22. Kumaria A, McConachie NS, Macarthur DC. Successful treatment of giant cavernous carotid artery aneurysm in a child using a flow diverter stent. Br J Neurosurg. 2021; Feb. 35(1):122–4.
Article
23. Li JS, Yow E, Berezny KY, Bokesch PM, Takahashi M, Graham TP, et al. Dosing of clopidogrel for platelet inhibition in infants and young children: Primary results of the Platelet Inhibition in Children On cLOpidogrel (PICOLO) trial. Circulation. 2008; Jan. 117(4):553–9.
Article
24. Lin N, Lanzino G, Lopes DK, Arthur AS, Ogilvy CS, Ecker RD, et al. Treatment of distal anterior circulation aneurysms with the pipeline embolization device: A US multicenter experience. Neurosurgery. 2016; Jul. 79(1):14–22.
Article
25. Lubicz B, Collignon L, Raphaeli G, Pruvo JP, Bruneau M, De Witte O, et al. Flow-diverter stent for the endovascular treatment of intracranial aneurysms: A prospective study in 29 patients with 34 aneurysms. Stroke. 2010; Oct. 41(10):2247–53.
Article
26. Mohammad LM, Coon AL, Carlson AP. Resolution of giant basilar artery aneurysm compression and reversal of sensorineural hearing loss with use of a flow diverter: Case report. J Neurosurg Pediatr. 2017; Jul. 20(1):81–5.
Article
27. Navarro R, Brown BL, Beier A, Ranalli N, Aldana P, Hanel RA. Flow diversion for complex intracranial aneurysms in young children. J Neurosurg Pediatr. 2015; Mar. 15(3):276–81.
Article
28. Peters PJ, Harrison T, Lennox JL. A dangerous dilemma: Management of infectious intracranial aneurysms complicating endocarditis. Lancet Infect Dis. 2006; Nov. 6(11):742–8.
Article
29. Samples DC, Ravindra VM, Thoms DJ, Tarasiewicz I, Grandhi R. Successful flow diversion treatment of ruptured infectious middle cerebral artery aneurysms with the use of Pipeline Flex with Shield technology. Interv Neuroradiol. 2021; Apr. 27(2):225–9.
Article
30. Saraf R, Shrivastava M, Siddhartha W, Limaye U. Intracranial pediatric aneurysms: Endovascular treatment and its outcome. J Neurosurg Pediatr. 2012; Sep. 10(3):230–40.
Article
31. Sastry RA, Koch MJ, Grannan BL, Stapleton CJ, Butler WE, Patel AB. Flow diversion of a recurrent, iatrogenic basilar tip aneurysm in a pediatric patient: Case report. J Neurosurg Pediatr. 2018; Jan. 21(1):90–3.
Article
32. Takemoto K, Tateshima S, Golshan A, Gonzalez N, Jahan R, Duckwiler G, et al. Endovascular treatment of pediatric intracranial aneurysms: a retrospective study of 35 aneurysms. J Neurointerv Surg. 2014; Jul. 6(6):432–8.
Article
33. Tonetti DA, Casillo SM, Jankowitz BT. Telescoping flow diverters for a pediatric fusiform distal anterior cerebral artery aneurysm: Technical case report. Childs Nerv Syst. 2021; Mar. 37(3):999–1002.
Article
34. Trivelato FP, Rezende MTS, Fonseca LV, Bonadio LE, Ulhôa AC, Abud DG. Pipeline embolization device for the treatment of a traumatic intracranial aneurysm in a child. Childs Nerv Syst. 2017; May. 33(5):869–72.
Article
35. Vachhani JA, Nickele CM, Elijovich L, Klimo P, Arthur AS. Flow diversion for treatment of growing A2 aneurysm in a child: Case report and review of flow diversion for intracranial aneurysms in pediatric patients. World Neurosurg. 2016; Dec. 96:607.
Article
36. Vargas SA, Diaz C, Herrera DA, Dublin AB. Intracranial aneurysms in children: The role of stenting and flow-diversion. J Neuroimaging. 2016; Jan-Feb. 26(1):41–5.
Article
37. Zarzecka A, Gory B, Turjman F. Implantation of two flow diverter devices in a child with a giant, fusiform vertebral artery aneurysm: Case report. Pediatr Neurol. 2014; Feb. 50(2):185–7.
Article
Full Text Links
  • JCEN
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr