J Nutr Health.
2024 Feb;57(1):16-26. 10.4163/jnh.2024.57.1.16.
Effects of autumn olive berry on insulin resistance and hyperglycemia in mice fed a high-fat, high-sucrose diet
- Affiliations
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- 1Department of Food and Nutrition, Changwon National University, Changwon 51140, Republic of Korea
- 2Department of Nutrition, Inje University, Haeundae Paik Hospital, Busan 48108, Republic of Korea
- 3Department of Digital Anti-aging Healthcare, Inje University, Gimhae 50834, Republic of Korea
- KMID: 2553701
- DOI: http://doi.org/10.4163/jnh.2024.57.1.16
Abstract
- Purpose
Type 2 diabetes mellitus is a metabolic condition marked by persistent elevated blood sugar levels resulting from insulin resistance. The effective management of diabetes mellitus involves strict regulation of the blood glucose levels. This study examined the effects of Autumn olive (Elaeagnus umbellata Thunb.) berry (AOB) on insulin resistance and hyperglycemia using a type 2 diabetes mellitus animal model.
Methods
Eight-week-old C57BL/6J mice were divided into four groups. The control group received a basal diet, while the high-fat, high-sucrose (HFHS) group was fed a HFHS diet containing 27% sucrose and 33% lard for 12 weeks. The low AOB (LAOB) and high AOB (HAOB) groups were offered a HFHS diet with a 0.5% and 1.0% AOB extract, respectively.
Results
The HAOB group showed significantly lower epididymal fat pad weight than the HFHS group. The LAOB and HAOB groups showed lower serum glucose levels and homeostasis model assessment for insulin resistance values than the HFHS group, and the HAOB group has lower serum insulin levels than the HFHS group. Supplementation with HAOB decreased serum cholesterol levels significantly compared with the HFHS group. The consumption of LAOB and HAOB reduced the serum triglyceride and hepatic total lipids and triglyceride levels compared to the HFHS group. In addition, LAOB and HAOB consumption in mice fed a HFHS diet increased adenosine monophosphate-activated protein kinase protein expression. Insulin receptor substrate-2 protein expression in the HAOB group was significantly higher than the HFHS group.
Conclusion
AOB can alleviate hyperglycemia in type 2 diabetes mellitus partly by mitigating insulin resistance.
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