Biomol Ther.  2024 Mar;32(2):192-204. 10.4062/biomolther.2023.118.

Inhaled Volatile Molecules-Responsive TRP Channels as Non-Olfactory Receptors

• Kim H
• Kim M
• Jang Y

• KMID: 2553502
• DOI: http://doi.org/10.4062/biomolther.2023.118

Abstract

Generally, odorant molecules are detected by olfactory receptors, which are specialized chemoreceptors expressed in olfactory neurons. Besides odorant molecules, certain volatile molecules can be inhaled through the respiratory tract, often leading to pathophysiological changes in the body. These inhaled molecules mediate cellular signaling through the activation of the Ca 2+ -permeable transient receptor potential (TRP) channels in peripheral tissues. This review provides a comprehensive overview of TRP channels that are involved in the detection and response to volatile molecules, including hazardous substances, anesthetics, plant-derived compounds, and pheromones. The review aims to shed light on the biological mechanisms underlying the sensing of inhaled volatile molecules. Therefore, this review will contribute to a better understanding of the roles of TRP channels in the response to inhaled molecules, providing insights into their implications for human health and disease.

Keyword

Transient receptor potential channel; TRPV1; TRPA1; Volatile organic compound; Non-olfactory receptors