Clin Exp Pediatr.  2024 Mar;67(3):140-148. 10.3345/cep.2023.00234.

Practical issues of oral immunotherapy for egg or milk allergy

• Kim S
• Ahn K
• Kim J

• KMID: 2553062
• DOI: http://doi.org/10.3345/cep.2023.00234

Abstract

Oral immunotherapy (OIT) has been recommended to reduce parental burden related to strict allergen avoidance and induce desensitization and immune tolerance for patients with long-lasting allergies to hen’s eggs (HE) or cow’s milk (CM). OIT should be monitored by pediatric allergists specializing in OIT and oral food challenge tests to manage allergic reactions. Although a previous history of anaphylaxis or multiple food allergies is not a contraindication to OIT, it is contraindicated if the patient has uncontrolled asthma, a malignancy, active systemic autoimmune disorders, or diseases requiring treatment with beta-blockers. A variety of OIT protocols have been de veloped to ensure better outcomes and safe up-dosing, including adjunctive therapies with biologics. This review provides insight into the practical issues of various immunotherapy options for children with HE or CM allergies.

Keyword

Egg allergy; Food allergy; Milk allergy; Oral food challenge; Oral immunotherapy