J Wound Manag Res.  2024 Feb;20(1):29-35. 10.22467/jwmr.2023.02761.

Experimental Study on Transverse-Axis Neovascularization of Acellular Dermal Matrix Using Platelet-Rich Plasma

• Yi HS
• Im HY
• Park JH
• Kim YS
• Oh SJ
• Kim HI

• KMID: 2552927
• DOI: http://doi.org/10.22467/jwmr.2023.02761

Abstract

Background
Acellular dermal matrices (ADMs) have shown promise in promoting tissue regeneration; however, their integration in challenging cases with limited vertical-axis neovascularization remains difficult. This study investigates whether clinically meaningful transverse-axis neovascularization is identified in ADM engraftment and whether this can be further accelerated by platelet-rich plasma (PRP).
Methods
ADM and PRP-soaked ADM were implanted into New Zealand rabbits, and histological analysis was performed at different periods to compare neovascularization.
Results
Histological analysis revealed that among 32 biopsy sites, there was transverse-axis neovascularization with an average length of 606.89 μm. When divided into two groups for assessing the impact of PRP on transverse-axis neovascularization, the extent of such neovascularization was measured as 582.99 μm in the control group and 630.79 μm in the experimental group. However, there was no statistically significant difference between the two groups (P=0.693).
Conclusion
The results of the present study indicate that achieving meaningful transverse-axis neovascularization in implanted ADMs remains a challenge, warranting further investigation into ADM structure and vertical-axis neovascularization.

Keyword

Acellular dermal matrix; Tissue engineering; Wound healing; Vascular remodeling; Platelet-rich plasma