Korean J Transplant.  2023 Nov;37(Suppl 1):S70. 10.4285/ATW2023.F-6477.

Gastrointestinal syndrome due to cytomegalovirus infection after kidney transplantation: a case report

• Wardhani AI
• Marbun MB

• KMID: 2551657
• DOI: http://doi.org/10.4285/ATW2023.F-6477

Abstract

Cytomegalovirus infection and disease in kidney transplantation are associated with an increased risk of allograft failure and mortality. Cytomegalovirus can establish latent infection after primary infection and can cause many clinical manifestations or syndromes, one of which occurs in the gastrointestinal tract. We present a 53-year-old man with chronic diarrhea, nausea, and malaise. He had a kidney transplantation four years ago with a seropositive immunoglobulin G (IgG) cytomegalovirus donor and recipient. He had seropositive IgM cytomegalovirus after having symptoms. These symptoms were previously treated with antibiotics and symptomatic drugs but did not recover. We treated the patient by giving valganciclovir, 450 mg thrice a day. He also replaced mycophenolate with tacrolimus because the initial test had decreased which increased the risk of allograft failure and after giving 0.5 mg twice-daily, it was stable at 5–10 ng/mL. The result of treatment was very satisfactory as indicated by recover of gastrointestinal syndrome, seronegative IgM cytomegalovirus, increased estimated glomerular filtration rate, and creatinine was stable.