Nat Prod Sci.
2023 Dec;29(4):287-290. 10.20307/nps.2023.29.4.287.
Macagigantin A, A New Flavonoid from Macaranga gigantea (Rchb.f & Zoll.) Mull.Arg
- Affiliations
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- 1Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, Indonesia
- 2Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Surabaya, Surabaya 60231, Indonesia
- 3Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia
- KMID: 2550565
- DOI: http://doi.org/10.20307/nps.2023.29.4.287
Abstract
- A new flavonol, macagigantin A (1), and three known flavonols (2–4) were isolated from Macaranga gigantea leaves. The structure of macagigantin A was fully assigned by 1D and 2D NMR, UV, and highresolution mass spectra data. The cytotoxic activity of 1–4 was evaluated against 4T1, P-388, and HeLa cells. Compound 1 showed potent activity against 4T1 cells with an IC 50 value of 1.18 μg/mL, and compound 3 showed moderate activity against P-388 cells (IC 50 value of 2.54 μg/mL).
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