J Pathol Transl Med.  2024 Jan;58(1):45-48. 10.4132/jptm.2023.12.11.

What’s new in genitourinary pathology 2023: WHO 5th edition updates for urinary tract, prostate, testis, and penis

• Choy B
• Tretiakova M
• Zynger DL

• KMID: 2550502
• DOI: http://doi.org/10.4132/jptm.2023.12.11

Abstract

The 5th edition WHO Classification of Urinary and Male Genital Tumours (2022) introduced many significant changes relevant to urologic daily practice, mainly to renal tumors which was covered in the What’s New newsletter in September 2022. In this newsletter, we summarize the notable changes to bladder, prostate, testis, and penis based on the 5th edition of the WHO.

Figure

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  Fig. 1. PIN-like prostatic adenocarcinoma. A. It is comprised of large discrete glands with flat or tufted pseudostratified epithelium. B. Immunostaining with HMWCK highlights lack of basal cells in PIN-like carcinoma focus.

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  Fig. 2. Teratoma with embryonic-type neuroectodermal tumor. The area with exclusive somatic malignancy spanned over 3 cm.

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  Fig. 3. Leydig cell tumor with lymphovascular invasion, categorized as high risk by LeSS.

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  Fig. 4. Signet ring stromal tumor. A. The tumor has large cytoplasmic vacuoles. B. Inhibin is negative. C. β-catenin has diffuse nuclear and cytoplasmic expression. D. Vimentin is diffusely positive.