J Dig Cancer Res.  2023 Dec;11(3):165-170. 10.52927/jdcr.2023.11.3.165.

Gastric Adenocarcinoma of Fundic-gland Type Diagnosed and Treated by Endoscopic Mucosal Resection

• Kim SE
• Park SJ
• Park MI
• Moon W
• Kim JH
• Jung K
• Kim BJ
• Chang HK

• KMID: 2549668
• DOI: http://doi.org/10.52927/jdcr.2023.11.3.165

Abstract

Gastric cancer is histologically classified into two types. One is the intestinal and diffuse type according to Lauren’s classification, and the other is the differentiated and undifferentiated type based on Nakamura’s classification. In 2007, Japanese groups proposed a new type of welldifferentiated gastric adenocarcinoma in the gastric fundic glands with distinct endoscopic and clinicopathologic features. This is gastric adenocarcinoma of the fundic-gland type (GA-FG), a rare variant of gastric cancer. In a 2012 Korean study, of 6,000 cases of gastric cancer tissues, only three cases of GA-FG were identified. GA-FG is usually located in the upper third of the stomach and not known to be associated with the Helicobacter pylori infection. We herein report a case of GA-FG diagnosed in a 63-year-old man. A gastric polyp was incidentally detected during an upper endoscopy screening while conducting a health check-up, and he was diagnosed with GA-FG after an endoscopic mucosal resection (EMR) was conducted for diagnostic and therapeutic purposes. Our case suggests that for both diagnostic and therapeutic purposes, EMR may be beneficial in case of gastric polyps with suspected GA-FG.

Keyword

Stomach neoplasms; Chief cells; Gastric; Endoscopic mucosal resection