J Gastric Cancer.  2021 Mar;21(1):103-109. 10.5230/jgc.2021.21.e11.

Long-term Observation of Gastric Adenocarcinoma of Fundic Gland Mucosa Type before and after Helicobacter pylori Eradication: a Case Report

• Takahashi K
• Ueno N
• Sasaki T
• Kobayashi Y
• Sugiyama Y
• Murakami Y
• Kunogi T
• Ando K
• Kashima S
• Moriichi K
• Tanabe H
• Kamikokura Y
• Yuzawa S
• Tanino M
• Okumura T
• Fujiya M

• KMID: 2526303
• DOI: http://doi.org/10.5230/jgc.2021.21.e11

Abstract

Gastric adenocarcinoma of the fundic gland mucosa type (GA-FGM) was proposed as a new variant of gastric adenocarcinoma of the fundic gland type (GA-FG). However, at present, the influence of Helicobacter pylori and the speed of progression and degree of malignancy in GA-FGM remain unclear. Herein, we report the first case of intramucosal GA-FGM that was endoscopically observed before and after H. pylori eradication over 15 years. The lesion showed the same tumor size with no submucosal invasion and a low MIB-1 labeling index 15 years after its detection using endoscopy. The endoscopic morphology changed from 0-IIa before H. pylori eradication to 0-IIa+IIc and then 0-I after H. pylori eradication. These findings suggest that the unaltered tumor size reflects low-grade malignancy and slow growth, and that the endoscopic morphology is influenced by H. pylori eradication.

Keyword

GA-FGM; Gastric adenocarcinoma of fundic gland type; GA-FG; Helicobacter pylori; Eradication