J Korean Dent Sci.  2023 Dec;16(2):164-171. 10.5856/JKDS.2023.16.2.164.

Antimicrobial Persistence of Silver Diamine Fluoride and Silver Fluoride against Streptococcus mutans

• Kim HJ
• An SY

• KMID: 2549611
• DOI: http://doi.org/10.5856/JKDS.2023.16.2.164

Abstract

Purpose
To evaluate the antimicrobial persistence of silver diamine fluoride (SDF) and silver fluoride (AgF) on Streptococcus mutans.
Materials and Methods
An in vitro experiment was conducted to observe changes in the diameter of the inhibition zone of various materials, including AgF (Riva Star Aqua™ step 1; SDI), potassium iodine (Riva star aqua™ step 2; SDI), Fluor protector^® (FP, Ivoclar Vivadent), SDF (Riva star™ step 1; SDI), Ampicillin (Sigma-Aldrich), Amphotericin B (Nexstar) and negative control on S. mutans. Result: SDF, AgF and FP exhibited significant antimicrobial persistence over the 4 weeks period (P<0.05). At day 28, the diameter of inhibition zone was larger in SDF than in AgF.
Conclusion
SDF and AgF have significant antibacterial durability against bacteria commonly associated with dental caries, with the antimicrobial effect lasting for at least 4 weeks. Further clinical studies are needed to validate these findings in vivo.

Keyword

Anti-bacterial agents; Dental caries; Fluorides