Ann Child Neurol.  2023 Apr;31(2):103-112. 10.26815/acn.2022.00409.

Clinicoepidemiological Profile and Prognostic Factors in Neurotuberculosis in Children

• Sharma V
• Rajeshwari K
• Kumar D
• Gupta G

• KMID: 2548606
• DOI: http://doi.org/10.26815/acn.2022.00409

Abstract

Purpose
This study aimed to determine the clinicoepidemiological profile and prognostic factors in children with neurotuberculosis.
Methods
An observational study was conducted at a tertiary care hospital on 50 children diagnosed with neurotuberculosis. The demographic profile, clinical details, and all investigations were recorded on a predetermined form and datasheet for analysis, and disability severity was graded using the modified Rankin Scale.
Results
Fifty patients were enrolled (male-to-female ratio, 1.08:1). Younger children (1 to 3 years) were more commonly affected. Most patients were malnourished, and only 58% had been immunized with the Bacillus Calmette-Guerin vaccine. Fever was the most common symptom (96%) followed by headache, altered consciousness, vomiting, seizures, and abnormal posture. On cerebrospinal fluid (CSF) analysis, 87% of patients showed pleocytosis with lymphocytic predominance. More than 80% of patients had CSF protein levels >100 mg/dL and CSF glucose levels <60 mg/dL. Common findings on neuroimaging were hydrocephalus (76%), basal meningeal enhancement (60%), basal exudates (52%), and parenchymal infarcts (32%). We noted a mortality rate of 40%, of whom 87.5% had modified British Medical Research Council (BMRC) stage 3 tubercular meningitis (TBM). All patients who survived stage 3 TBM had a severe disability, and over 50% of patients with stage 2 TBM had moderate to severe disabilities.
Conclusion
Young age, lower socioeconomic status, BMRC stages 2 and 3, abnormal posture, hydrocephalus, and the presence of basal exudates were associated with poor outcomes. High suspicion is needed for early diagnosis and prevention of disability and mortality.

Keyword

Neurotuberculosis; Clinical profile; Cerebrospinal fluid; Neuroimaging; Prognosis