J Neurogastroenterol Motil.
2023 Oct;29(4):470-477. 10.5056/jnm23088.
Real-world Prescription Patterns and Patient Satisfaction Regarding Maintenance Therapy of Gastroesophageal Reflux Disease: An Observational, Cross-sectional, Multicenter Study
- Affiliations
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- 1Department of Internal Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
- 2Department of Statistics, Keimyung University, Daegu, Korea
- 3Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
- 4Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
- 5Department of Internal Medicine, College of Medicine, Hallym University, Chuncheon, Gangwon-do, Korea
- 6Division of Gastroenterology, Department of Internal Medicine, College of Medicine, Konyang University, Daejeon, Korea
- 7Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea
- 8Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea
- 9Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea
- 10Department of Internal Medicine, Daegu Catholic University School of Medicine, Daegu, Korea;
- 11Department of Internal Medicine, Dongguk University College of Medicine, Goyang, Gyeonggi-do, Korea
- 12Departments of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, Korea
- 13Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
- 14Department of Internal Medicine, Soonchunhyang University, Bucheon, Gyeonggi-do, Korea
- 15Health Promotion, Gangnam Severance Hospital, Seoul, Korea
- 16Department of Gastroenterology, Wonkwang University School of Medicine, Iksan, Jeollabuk-do, Korea
- 17Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, Korea
- 18Department of Internal Medicine, Gyeongsang National University Changwon Hospital, Gyeongsang National University College of Medicine, Changwon, Gyeongsangnam-do, Korea
- 19Department of Gastroenterology, Ajou University School of Medicine, Suwon, Gyeonggi-do, Korea
- KMID: 2546971
- DOI: http://doi.org/10.5056/jnm23088
Abstract
- Background/Aims
Gastroesophageal reflux disease (GERD) is a common chronic gastrointestinal disorder that typically requires long-term maintenance therapy. However, little is known about patient preferences and satisfaction and real-world prescription patterns regarding maintenance therapy for GERD.
Methods
This observational, cross-sectional, multicenter study involved patients from 18 referral hospitals in Korea. We surveyed patients who had been prescribed proton pump inhibitors (PPIs) for GERD for at least 90 days with a minimum follow-up duration of 1 year. The main outcome was overall patient satisfaction with different maintenance therapy modalities.
Results
A total of 197 patients were enrolled. Overall patient satisfaction, patient preferences, and GERD health-related quality of life scores did not significantly differ among the maintenance therapy modality groups. However, the on-demand therapy group experienced a significantly longer disease duration than the continuous therapy group. The continuous therapy group demonstrated a lower level of awareness of potential adverse effects associated with PPIs than the on-demand therapy group but received higher doses of PPIs than the on-demand therapy group. The prescribed doses of PPIs also varied based on the phenotype of GERD, with higher doses prescribed for non-erosive reflux disease than erosive reflux disease.
Conclusion
Although overall patient satisfaction did not significantly differ among the different PPI maintenance therapy modality groups, awareness of potential adverse effects was significantly different between the on-demand and continuous therapy groups.
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