J Mov Disord.  2023 Sep;16(3):231-247. 10.14802/jmd.23065.

Nine Hereditary Movement Disorders First Described in Asia: Their History and Evolution

• Jagota P
• Ugawa Y
• Aldaajani Z
• Ibrahim NM
• Ishiura H
• Nomura Y
• Tsuji S
• Diesta C
• Hattori N
• Onodera O
• Bohlega S
• Al-Din A
• Lim SY
• Lee JY
• Jeon B
• Pal PK
• Shang H
• Fujioka S
• Kukkle PL
• Phokaewvarangkul O
• Lin CH
• Shambetova C
• Bhidayasiri R

• KMID: 2545921
• DOI: http://doi.org/10.14802/jmd.23065

Abstract

Clinical case studies and reporting are important to the discovery of new disorders and the advancement of medical sciences. Both clinicians and basic scientists play equally important roles leading to treatment discoveries for both cures and symptoms. In the field of movement disorders, exceptional observation of patients from clinicians is imperative, not just for phenomenology but also for the variable occurrences of these disorders, along with other signs and symptoms, throughout the day and the disease course. The Movement Disorders in Asia Task Force (TF) was formed to help enhance and promote collaboration and research on movement disorders within the region. As a start, the TF has reviewed the original studies of the movement disorders that were preliminarily described in the region. These include nine disorders that were first described in Asia: Segawa disease, PARK-Parkin, X-linked dystonia-parkinsonism, dentatorubral-pallidoluysian atrophy, Woodhouse-Sakati syndrome, benign adult familial myoclonic epilepsy, Kufor-Rakeb disease, tremulous dystonia associated with mutation of the calmodulin-binding transcription activator 2 gene, and paroxysmal kinesigenic dyskinesia. We hope that the information provided will honor the original researchers and help us learn and understand how earlier neurologists and basic scientists together discovered new disorders and made advances in the field, which impact us all to this day.

Keyword

KeywordsaaAsia; Gene; Genetics; Hereditary; History; Movement disorders