Korean J Intern Med.  2023 Sep;38(5):661-671. 10.3904/kjim.2022.394.

Real-world effectiveness and safety of adalimumab in Korean patients with intestinal Behcet’s disease: a Korean Association for the Study of Intestinal Diseases (KASID) multicenter study

• Lee SB
• Hong HS
• Lee CK
• Lee BI
• Kim S
• Koh SJ
• Yu H
• Park JB
• Hwang SW
• Ye BD
• Yang SK
• Park SH
• on behalf of the IBD Research Group of the Korean Association for the Study of Intestinal Diseases (KASID)

• KMID: 2545691
• DOI: http://doi.org/10.3904/kjim.2022.394

Abstract

Background/Aims
The short- and long-term effects of adalimumab (ADA) on Korean patients with intestinal Behcet’s disease (BD) for remain unclear. Therefore, a multicenter study was performed to evaluate the efficacy and safety of ADA in Korean patients with intestinal BD in a real-world setting.
Methods
The medical records of 67 patients with BD prescribed ADA between January 2012 and December 2020 at five referral centers in Korea were retrospectively analyzed and the safety and efficacy of ADA within 52 weeks were assessed. To evaluate the clinical efficacy of ADA, the Disease Activity Index for Intestinal BD (DAIBD) and representative blood biochemical markers were compared at 0, 12, 24, and 52 weeks of ADA treatment.
Results
During the follow-up period of 52 weeks, 46 patients continued ADA treatment. The cumulative drug survival rate was 83.5%. The DAIBD score decreased over the study period (p < 0.001). Moreover, the erythrocyte sedimentation rate, serum C-reactive protein levels, and serum albumin levels significantly improved at 12, 24, and 52 weeks of ADA treatment (all, p <0.05).
Conclusions
As ADA is effective for refractory intestinal BD with few safety concerns in real-world situations, it is a potential treatment option for Korean patients with intestinal BD.

Keyword

Adalimumab; Behcet syndrome; Treatment outcome