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Is adalimumab safe and effective in patients with intestinal Behcet’s disease in real-world practice?

Suzuki Y, Hagiwara T, Kobayashi M, Morita K, Shimamoto T, Hibi T

Background/Aims: The safety and effectiveness of adalimumab was demonstrated in a phase 3 trial in Japanese patients with intestinal Behçet’s disease. The aim of this study was to evaluate the...
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Palisaded Neutrophilic and Granulomatous Dermatitis in a Patient with Behçet’s Disease: A Case Report

Shin YB, Jo JW, Yoon TJ

Palisaded neutrophilic and granulomatous dermatitis (PNGD) is an uncommon skin eruption and characterized histopathologically by the presence of granulomatous inflammation with or without leukocytoclastic vasculitis. PNGD is known to be...
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Epidemiologic and Etiological Features of Korean Patients With Behçet’s Disease

Choi SH, Kim DY

Behçet’s disease (BD) is a multisystem disease in which environmental factors provoke an adverse immune response in patients with genetic susceptibility towards BD, subsequently leading to a cascade of dysregulated...
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Is There a Correlation Between Behçet Disease and Lower Urinary Tract Symptoms?

Baser A, Zumrutbas AE, Ozlulerden Y, Alkıs O, Oztekın A, Celen S, Aybek Z

Purpose: In this study, we aimed to determine the prevalence of lower urinary tract symptoms (LUTS) in patients with Behçet disease (BD) and to investigate the relationship between the severity...
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Comparison of Clinical, Angiographic Features and Outcome in Takayasu's Arteritis and Behçet's Disease With Arterial Involvement

Choi SJ, Koo HJ, Yang DH, Kang JW, Oh JS, Hong S, Kim YG, Yoo B, Lee CK

OBJECTIVE: Takayasu's arteritis (TAK) is a vasculitis that primarily involves the aorta and its branches. In Behçet's disease (BD), systemic vasculitis is one of major manifestations. We aimed to compare...
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Characterization of Venous Involvement in Vasculo-Behçet Disease

Lee NH, Bae M, Jin M, Chung SW, Lee CW, Jeon CH

Background: Behçet disease is a chronic inflammatory disorder with a varying etiology. Herein, we report the involvement of peripheral veins in Behçet disease and discuss the treatment thereof. Methods: Thirty-four patients with...
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Long-term outcome after surgery in a patient with intestinal Behçet’s disease complicated by myelodysplastic syndrome and trisomy 8

Mori Y, Iwamoto F, Ishida Y, Kuno T, Kobayashi S, Yoshida T, Yamaguchi T, Sato T, Sudo M, Ichikawa D, Enomoto N

Behçet’s disease (BD) is a multisystem inflammatory disease of unknown origin. Rarely, BD occurs together with myelodysplastic syndrome (MDS). Interestingly, it is speculated that these are not simple coexistence but...
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Measurement of Contrast Sensitivity in Patients with Behçet's Disease without Ocular Involvement

Ozsoy E, Cankaya C, Ozturk E, Gunduz A, Ulucan PB

PURPOSE: To evaluate contrast sensitivity in patients with Behçet's disease (BD) without ocular involvement. METHODS: The study group was composed of 47 BD patients (20 to 50 years of age) who...
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Effect of Long-term Comprehensive Rehabilitation on Functional Recovery in Recurrent and Refractory Neuro-Behcet's Disease: a Case Report with 4-year Follow-up

Park JW, Joo MC, Lee KM, Kim MS

Neuro-Behcet's disease (NBD) is rare, but it is the most serious complication of Behcet's disease, a vasculitis and multisystem inflammatory syndrome. NBD causes a variety of neurological deficits depending on...
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Clinical phenotypes of Korean patients with Behcet disease according to gender, age at onset, and HLA-B51

Ryu HJ, Seo MR, Choi HJ, Baek HJ

BACKGROUND/AIMS: The clinical manifestations of Behcet disease (BD) have been reported to differ according to country, region, and race. Gender, onset age, and human leukocyte antigen (HLA)-B51 have also been...
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Choroidal Thickness Indicates Subclinical Ocular and Systemic Inflammation in Eyes with Behçet Disease without Active Inflammation

Chung YR, Cho EH, Jang S, Lee SY, Lee ES, Lee K

PURPOSE: To investigate whether subfoveal choroidal thickness, measured using enhanced depth imaging optical coherence tomography (EDI-OCT), is an indicator of subclinical ocular or systemic inflammation in eyes with Behçet disease...
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Immunohistochemical differentiation between chronic enteropathy associated with SLCO2A1 gene and other inflammatory bowel diseases

Yamaguchi , Yanai S, Nakamura S, Kawasaki K, Eizuka M, Uesugi N, Sugai T, Umeno J, Esaki M, Matsumoto

BACKGROUND/AIMS: We recently identified recessive mutations in the solute carrier organic anion transporter family member 2A1 gene (SLCO2A1) as causative variants of chronic enteropathy associated with SLCO2A1 (CEAS). The aim...
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A Case of Behçet's Disease Mimicking Vertebral Invasion of a Mycotic Aneurysm

Son HJ, Choi S, Jung KH, Cheong M, Lee I, Hong S, Chong YP

Behçet's disease is a systemic vasculitis of unknown etiology characterized by recurrent oral and genital ulcers and uveitis. The vascular involvement of Behçet's disease affects arteries, veins, and blood vessels...
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Development of a Novel Endoscopic Scoring System to Predict Relapse after Surgery in Intestinal Behçet's Disease

Park JW, Park Y, Park SJ, Kim TI, Kim WH, Cheon JH

BACKGROUND/AIMS: The cumulative surgery rate and postoperative relapse of intestinal Behcet’s disease (BD) have been reported to be high. This study aimed to establish a scoring system based on follow-up...
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Anti-Tumor Necrosis Factor Therapy in Intestinal Behçet's Disease

Park J, Cheon JH

Intestinal Behçet's disease is a rare, immune-mediated chronic intestinal inflammatory disease; therefore, clinical trials to optimize the management and treatment of patients are scarce. Moreover, intestinal Behçet's disease is difficult...
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Behçet's disease with multiple splenic abscesses in a child

Lim KI, Yang DH, Ryoo E

We report the case of a 5-year-old male patient with multiple aseptic splenic abscesses associated with Behçet's disease. The patient visited Gachon University Gil Hospital with fever, abdominal pain, and...
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Optimal diagnosis and disease activity monitoring of intestinal Behçet's disease

Lee HJ, Cheon JH

Intestinal Behçet's disease (BD), generally accepted as a type of inflammatory bowel disease (IBD), could be diagnosed when patients with BD have objectively documented gastrointestinal symptoms and intestinal ulcerations. Similar...
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Transcription Factors Regulating Inflammatory Cytokine Production Are Differentially Expressed in Peripheral Blood Mononuclear Cells of Behçet Disease Depending on Disease Activity

Woo MY, Yun SJ, Lee MJ, Kim K, Lee ES, Park S

BACKGROUND: Behçet disease (BD) is a relapsing inflammatory disease with increased production of inflammatory cytokines in peripheral blood mononuclear cells (PBMCs); however, the underlying molecular mechanisms are not well known. OBJECTIVE:...
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Association of sleep quality in Behcet disease with disease activity, depression, and quality of life in Korean population

Lee J, Kim SS, Jeong HJ, Son CN, Kim JM, Cho YW, Kim SH

BACKGROUND/AIMS: Sleep disturbance is prime concern in patients with Behcet disease. The purpose of this study was to find out the effects of sleep quality, in Korean patients suffering from...
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Thiopurine S-Methyltransferase Polymorphisms in Korean Dermatologic Patients

Lee M, Seo J, Bang D, Kim DY

BACKGROUND: Thiopurine S-methyltransferase (TPMT) is an important enzyme in the metabolism of thiopurines including azathioprine (AZA), 6-mercaptopurine, and 6-thioguanine. TPMT genotyping is widely used for screening of AZA-related toxicity during...
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